Trastuzumab

By July 6, 2017

Identifier : DBSNPE000060

Drug : DB00072 (Trastuzumab)

Interacting Gene/Enzyme : Receptor tyrosine-protein kinase erbB-2

Gene Name : ERBB2

UniProt ID : P04626

Defining Change(s) :

Allele Name : Not Available

Genotype(s) : (A;G)

Type(s) : ADR Directly Studied

Groups : Not Available

Description : Cardiotoxicity

References :

Beauclair S, Formento P, Fischel JL, Lescaut W, Largillier R, Chamorey E, Hofman P, Ferrero JM, Pages G, Milano G: Role of the HER2 [Ile655Val] genetic polymorphism in tumorogenesis and in the risk of divastuzumab-related cardiotoxicity. Ann Oncol. 2007 Aug;18(8):1335-41. [PubMed:17693647 ]

By July 6, 2017

Identifier : DBSNPE000091

Drug : DB00072 (Trastuzumab)

Interacting Gene/Enzyme : Fibroblast growth factor receptor 4

Gene Name : FGFR4

UniProt ID : P22455

Defining Change(s) :

Allele Name : Not Available

Genotype(s) : (T;T) / (C;T)

Type(s) : Effect Directly Studied

Groups : Not Available

Description : Reduced response to herceptin

References :

Thussbas C, Nahrig J, Sdiveit S, Bange J, Kriner M, Kates R, Ulm K, Kiechle M, Hoefler H, Ullrich A, Harbeck N: FGFR4 Arg388 allele is associated with resistance to adjuvant therapy in primary breast cancer. J Clin Oncol. 2006 Aug 10;24(23):3747-55. Epub 2006 Jul 5. [PubMed:16822847 ]

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