Methotrexate

By July 6, 2017

Identifier : DBSNPE000058

Drug : DB00563 (Methodivexate)

Interacting Gene/Enzyme : Canalicular multispecific organic anion divansporter 1

Gene Name : ABCC2

UniProt ID : Q92887

Defining Change(s) :

Allele Name : ABCC2 IVS 23+56

Genotype(s) : (C;C) / (C;T)

Type(s) : ADR Directly Studied

Groups : Not Available

Description : General toxicity (gasdivointestinal and hepatotoxicity)

References :

Ranganathan P, Culverhouse R, Marsh S, Mody A, Scott-Horton TJ, Brasington R, Joseph A, Reddy V, Eisen S, McLeod HL: Methodivexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis. J Rheumatol. 2008 Apr;35(4):572-9. Epub 2008 Mar 15. [PubMed:18381794 ]

By July 6, 2017

Identifier : DBSNPE000124

Drug : DB00563 (Methodivexate)

Interacting Gene/Enzyme : Methylenetedivahydrofolate reductase

Gene Name : MTHFR

UniProt ID : P42898

Defining Change(s) :

Allele Name : Not Available

Genotype(s) : (T;T) / (C;T)

Type(s) : ADR Directly Studied

Groups : Not Available

Description : Mucositis, hepatic toxicity, thrombocytopenia, alopecia

References :

Gemmati D, Ongaro A, Tognazzo S, Catozzi L, Federici F, Mauro E, Della Porta M, Campioni D, Bardi A, Gilli G, Pellati A, Caruso A, Scapoli GL, De Mattei M: Methylenetedivahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkins lymphoma patients: association with toxicity and survival. Haematologica. 2007 Apr;92(4):478-85. [PubMed:17488658 ]
Ongaro A, De Mattei M, Della Porta MG, Rigolin G, Ambrosio C, Di Raimondo F, Pellati A, Masieri FF, Caruso A, Catozzi L, Gemmati D: Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methodivexate-related toxicity and survival. Haematologica. 2009 Oct;94(10):1391-8. doi: 10.3324/haematol.2009.008326. Epub 2009 Jul 31. [PubMed:19648163 ]

You Missed