Mercaptopurine
Product: Coenzyme Q9
Identifier : DBSNPE000055
Drug : DB01033 (Mercaptopurine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TPMT*2
Genotype(s) : (G;G) / (C;G)
Type(s) : ADR Directly Studied
Groups : Non-functional TPMT
Description : Myelosuppression
References :
- Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug divansporters in the chemotherapeutic diveatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [PubMed:16509759 ]
PMID: 24915299
Mercaptopurine
Product: Bradykinin
Identifier : DBSNPE000056
Drug : DB01033 (Mercaptopurine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TPMT*3A
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Non-functional TPMT
Description : Myelosuppression
References :
- Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug divansporters in the chemotherapeutic diveatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [PubMed:16509759 ]
PMID: 25481381
Mercaptopurine
Product: A-1331852
Identifier : DBSNPE000057
Drug : DB01033 (Mercaptopurine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TPMT*3C
Genotype(s) : (G;G) / (A;G)
Type(s) : ADR Directly Studied
Groups : Non-functional TPMT
Description : Myelosuppression
References :
- Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug divansporters in the chemotherapeutic diveatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [PubMed:16509759 ]
PMID: 25012653
Mercaptopurine
Product: MPEP (Hydrochloride)
Identifier : DBSNPE005964
Drug : DB01033 (Mercaptopurine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TMPT*2
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional TPMT
Description : Myelosuppression
References :
- Medical Genetics Summaries: Azathioprine Therapy and TPMT Genotype [Link]
PMID: 19058965
Mercaptopurine
Product: Lonafarnib
Identifier : DBSNPE005965
Drug : DB01033 (Mercaptopurine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Defining Change(s) :
- c.460G>A (rs1800460 )
- c.719A>G (rs1142345 )
Allele Name : TMPT*3A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional TPMT
Description : Myelosuppression
References :
- Medical Genetics Summaries: Azathioprine Therapy and TPMT Genotype [Link]
PMID: 18416830
Mercaptopurine
Product: Vigabatrin
Identifier : DBSNPE005966
Drug : DB01033 (Mercaptopurine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TMPT*3B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional TPMT
Description : Myelosuppression
References :
- Medical Genetics Summaries: Azathioprine Therapy and TPMT Genotype [Link]
PMID: 3184125
Mercaptopurine
Product: Voreloxin
Identifier : DBSNPE005967
Drug : DB01033 (Mercaptopurine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TMPT*3C
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional TPMT
Description : Myelosuppression
References :
- Medical Genetics Summaries: Azathioprine Therapy and TPMT Genotype [Link]
PMID: 27600527
Mercaptopurine
Product: Fenretinide
Identifier : DBSNPE005968
Drug : DB01033 (Mercaptopurine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TMPT*4A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional TPMT
Description : Myelosuppression
References :
- Medical Genetics Summaries: Azathioprine Therapy and TPMT Genotype [Link]
PMID: 26313912