PI3KInhibitorpi3kinhibitor

Isoniazid

By

Isoniazid

Product: MK-0557

Identifier : DBSNPE000054
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Cytochrome P450 2E1
Gene Name : CYP2E1
UniProt ID : P05181
Defining Change(s) :

  • G Allele, homozygote (rs6413419 )

Allele Name : CYP2E1 *1A
Genotype(s) : (G;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Hepatotoxicity
References :

  1. Vuilleumier N, Rossier MF, Chiappe A, Degoumois F, Dayer P, Mermillod B, Nicod L, Desmeules J, Hochsdivasser D: CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients diveated for latent tuberculosis. Eur J Clin Pharmacol. 2006 Jun;62(6):423-9. Epub 2006 Apr 27. [PubMed:16770646 ]

PMID: 25243776

Isoniazid

By

Isoniazid

Product: Terlipressin

Identifier : DBSNPE000685
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 1
Gene Name : NAT1
UniProt ID : P18440
Defining Change(s) :

  • G > A | T > A | C > A (rs4986782 )

Allele Name : NAT1*14A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25866967

Isoniazid

By

Isoniazid

Product: TBHQ

Identifier : DBSNPE000686
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 1
Gene Name : NAT1
UniProt ID : P18440
Defining Change(s) :

  • G > A (rs4986782 )

Allele Name : NAT1*14B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25345855

Isoniazid

By

Isoniazid

Product: BTTAA

Identifier : DBSNPE000687
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 1
Gene Name : NAT1
UniProt ID : P18440
Defining Change(s) :

  • C > T (rs5030839 )

Allele Name : NAT1*15
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 26218671

Isoniazid

By

Isoniazid

Product: Talarozole (R enantiomer)

Identifier : DBSNPE000688
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 1
Gene Name : NAT1
UniProt ID : P18440
Defining Change(s) :

  • C > T (rs56379106 )

Allele Name : NAT1*17
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 26549851

Isoniazid

By

Isoniazid

Product: SAR405

Identifier : DBSNPE000689
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 1
Gene Name : NAT1
UniProt ID : P18440
Defining Change(s) :

  • C > T (rs56318881 )

Allele Name : NAT1*19A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 26220942

Isoniazid

By

Isoniazid

Product: NK-252

Identifier : DBSNPE000690
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 1
Gene Name : NAT1
UniProt ID : P18440
Defining Change(s) :

  • C > T | C > T (rs56318881 )

Allele Name : NAT1*19B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 26395143

Isoniazid

By

Isoniazid

Product: A-804598

Identifier : DBSNPE000691
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 1
Gene Name : NAT1
UniProt ID : P18440
Defining Change(s) :

  • A > T (rs56172717 )

Allele Name : NAT1*22
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25970290

Isoniazid

By

Isoniazid

Product: IMR-1A

Identifier : DBSNPE000692
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | C > T (rs1801280 )

Allele Name : NAT2*5A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 26713239

Isoniazid

By

Isoniazid

Product: TCS-OX2-29

Identifier : DBSNPE000693
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | C > T | A > G (rs1801280 )

Allele Name : NAT2*5B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 26121747

Isoniazid

By

Isoniazid

Product: IMR-1

Identifier : DBSNPE000694
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | A > G (rs1801280 )

Allele Name : NAT2*5C
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25448845

Isoniazid

By

Isoniazid

Product: CFMTI

Identifier : DBSNPE000695
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C (rs1801280 )

Allele Name : NAT2*5D
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 26104416

Isoniazid

By

Isoniazid

Product: FPTQ

Identifier : DBSNPE000696
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | G > A (rs1801280 )

Allele Name : NAT2*5E
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25398695

Isoniazid

By

Isoniazid

Product: Hederacoside C

Identifier : DBSNPE000697
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | C > T | C > T | A > G (rs1801280 )

Allele Name : NAT2*5F
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25658373

Isoniazid

By

Isoniazid

Product: Echinocystic acid

Identifier : DBSNPE000698
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | C > T | C > T | A > G (rs1801280 )

Allele Name : NAT2*5G
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 26607280

Isoniazid

By

Isoniazid

Product: Pulchinenoside C

Identifier : DBSNPE000699
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | C > T | A > G | S287 Frameshift (rs1801280 )

Allele Name : NAT2*5H
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 26573335

Isoniazid

By

Isoniazid

Product: Pulchinenoside A

Identifier : DBSNPE000700
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | C > T | A > T | A > G (rs1801280 )

Allele Name : NAT2*5I
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25658089

Isoniazid

By

Isoniazid

Product: Cyclic somatostatin

Identifier : DBSNPE000701
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | C > T | G > A (rs1801280 )

Allele Name : NAT2*5J
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25448007

Isoniazid

By

Isoniazid

Product: Nafarelin

Identifier : DBSNPE000702
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | C > T (rs1799930 )

Allele Name : NAT2*6A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 26278042

Isoniazid

By

Isoniazid

Product: Argipressin

Identifier : DBSNPE000703
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A (rs1799930 )

Allele Name : NAT2*6B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25954501

Isoniazid

By

Isoniazid

Product: Epetraborole (hydrochloride)

Identifier : DBSNPE000704
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | C > T | A > G (rs1799930 )

Allele Name : NAT2*6C
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25741001

Isoniazid

By

Isoniazid

Product: Ro 67-7476

Identifier : DBSNPE000705
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | C > T | T > C (rs1799930 )

Allele Name : NAT2*6D
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25884855

Isoniazid

By

Isoniazid

Product: MK-4101

Identifier : DBSNPE000706
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | C > T (rs1799930 )

Allele Name : NAT2*6E
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25955532

Isoniazid

By

Isoniazid

Product: N-Acetylneuraminic acid

Identifier : DBSNPE000707
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A (rs1799931 )

Allele Name : NAT2*7A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25828472

Isoniazid

By

Isoniazid

Product: Homatropine (methylbromide)

Identifier : DBSNPE000708
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | C > T (rs1799931 )

Allele Name : NAT2*7B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 26473351

Isoniazid

By

Isoniazid

Product: Sapropterin (dihydrochloride)

Identifier : DBSNPE000709
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A (rs72554617 )

Allele Name : NAT2*10
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25024431

Isoniazid

By

Isoniazid

Product: CGP 25454A

Identifier : DBSNPE000710
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | A > G (rs4986996 )

Allele Name : NAT2*12D
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25266657

Isoniazid

By

Isoniazid

Product: TCV-309 (chloride)

Identifier : DBSNPE000711
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A (rs1801279 )

Allele Name : NAT2*14A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25471520

Isoniazid

By

Isoniazid

Product: Triptorelin

Identifier : DBSNPE000712
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | C > T (rs1801279 )

Allele Name : NAT2*14B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25205843

Isoniazid

By

Isoniazid

Product: Tramiprosate

Identifier : DBSNPE000713
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | T > C | C > T | A > G (rs1801279 )

Allele Name : NAT2*14C
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25745638

Isoniazid

By

Isoniazid

Product: Tubacin

Identifier : DBSNPE000714
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | C > T | G > A (rs1801279 )

Allele Name : NAT2*14D
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 24925468

Isoniazid

By

Isoniazid

Product: Deslorelin

Identifier : DBSNPE000715
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | A > G (rs1801279 )

Allele Name : NAT2*14E
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 24651281

Isoniazid

By

Isoniazid

Product: NVP-BAW2881

Identifier : DBSNPE000716
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | T > C | A > G (rs1801279 )

Allele Name : NAT2*14F
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 24709321

Isoniazid

By

Isoniazid

Product: Tetrabenazine (Racemate)

Identifier : DBSNPE000717
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | C > T | A > G (rs1801279 )

Allele Name : NAT2*14G
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 24440272

Isoniazid

By

Isoniazid

Product: Dapiprazole (hydrochloride)

Identifier : DBSNPE000718
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • A > C (rs72554616 )

Allele Name : NAT2*17
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 25422477

Isoniazid

By

Isoniazid

Product: PD168393

Identifier : DBSNPE000719
Drug : DB00951 (Isoniazid)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • C > T (rs1805158 )

Allele Name : NAT2*19
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Increased risk of toxic reactions.
References :

  1. Rifater®[package insert]. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2013. [Link]

PMID: 24895131

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