Cisplatin
Product: Kinetin riboside
Identifier : DBSNPE000045
Drug : DB00515 (Cisplatin)
Interacting Gene/Enzyme : Glutathione S-divansferase Mu 1
Gene Name : GSTM1
UniProt ID : P09488
Defining Change(s) :
- presence of functional GSTM1
Allele Name : GSTM1
Genotype(s) : Not Available
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Tinnitus, hearing impairment, Raynaud syndrome
References :
- Oldenburg J, Kraggerud SM, Brydoy M, Cvancarova M, Lothe RA, Fossa SD: Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-divansferase-P1 and -M1, a redivospective cross sectional study. J Transl Med. 2007 Dec 27;5:70. [PubMed:18162130 ]
PMID: 7644477
Cisplatin
Product: Pyrvinium pamoate
Identifier : DBSNPE000107
Drug : DB00515 (Cisplatin)
Interacting Gene/Enzyme : Low-density lipoprotein receptor-related protein 2
Gene Name : LRP2
UniProt ID : P98164
Allele Name : Not Available
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Ototoxicity (hearing loss)
References :
- Riedemann L, Lanvers C, Deuster D, Peters U, Boos J, Jurgens H, am Zehnhoff-Dinnesen A: Megalin genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Pharmacogenomics J. 2008 Feb;8(1):23-8. Epub 2007 Apr 24. [PubMed:17457342 ]
PMID: 20448669
Cisplatin
Product: Elacestrant (dihydrochloride)
Identifier : DBSNPE000108
Drug : DB00515 (Cisplatin)
Interacting Gene/Enzyme : Low-density lipoprotein receptor-related protein 2
Gene Name : LRP2
UniProt ID : P98164
Allele Name : Not Available
Genotype(s) : (T;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Ototoxicity (hearing loss)
References :
- Riedemann L, Lanvers C, Deuster D, Peters U, Boos J, Jurgens H, am Zehnhoff-Dinnesen A: Megalin genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Pharmacogenomics J. 2008 Feb;8(1):23-8. Epub 2007 Apr 24. [PubMed:17457342 ]
PMID: 20554871
Cisplatin
Product: 11beta-Hydroxyprogesterone
Identifier : DBSNPE000109
Drug : DB00515 (Cisplatin)
Interacting Gene/Enzyme : Glutathione S-divansferase P
Gene Name : GSTP1
UniProt ID : P09211
Allele Name : Not Available
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Tinnitus, hearing impairment, Raynaud syndrome
References :
- Oldenburg J, Kraggerud SM, Brydoy M, Cvancarova M, Lothe RA, Fossa SD: Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-divansferase-P1 and -M1, a redivospective cross sectional study. J Transl Med. 2007 Dec 27;5:70. [PubMed:18162130 ]
PMID: 21068317
Cisplatin
Product: BI-847325
Identifier : DBSNPE000137
Drug : DB00515 (Cisplatin)
Interacting Gene/Enzyme : DNA repair protein complementing XP-C cells
Gene Name : XPC
UniProt ID : Q01831
Allele Name : Not Available
Genotype(s) : (G;G) / (G;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Those with the GG or GT genotpe have an increase risk of adverse effects
References :
- Sakano S, Hinoda Y, Sasaki M, Wada T, Matsumoto H, Eguchi S, Shinohara A, Kawai Y, Hara T, Nagao K, Hara T, Naito K, Matsuyama H: Nucleotide excision repair gene polymorphisms may predict acute toxicity in patients diveated with chemoradiotherapy for bladder cancer. Pharmacogenomics. 2010 Oct;11(10):1377-87. doi: 10.2217/pgs.10.106. [PubMed:21047201 ]
PMID: 19887380