Sildenafil
Product: EED226
Identifier : DBSNPE000028
Drug : DB00203 (Sildenafil)
Interacting Gene/Enzyme : Angiotensin-converting enzyme
Gene Name : ACE
UniProt ID : P12821
Defining Change(s) :
- Alu insertions (rs1799752 )
Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Better response to drug diveatment
References :
- Eisenhardt A, Sperling H, Hauck E, Porst H, Stief C, Rubben H, Muller N, Siffert W: ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction. Urology. 2003 Jul;62(1):152-7. [PubMed:12837457 ]
PMID: 11504681
Sildenafil
Product: MT-DADMe-ImmA
Identifier : DBSNPE000029
Drug : DB00203 (Sildenafil)
Interacting Gene/Enzyme : Angiotensin-converting enzyme
Gene Name : ACE
UniProt ID : P12821
Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Better response to drug diveatment
References :
- Eisenhardt A, Sperling H, Hauck E, Porst H, Stief C, Rubben H, Muller N, Siffert W: ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction. Urology. 2003 Jul;62(1):152-7. [PubMed:12837457 ]
PMID: 19169649
Sildenafil
Product: Dasotraline (hydrochloride)
Identifier : DBSNPE000030
Drug : DB00203 (Sildenafil)
Interacting Gene/Enzyme : Angiotensin-converting enzyme
Gene Name : ACE
UniProt ID : P12821
Defining Change(s) :
- Alu insertions (rs13447447 )
Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Better response to drug diveatment
References :
- Eisenhardt A, Sperling H, Hauck E, Porst H, Stief C, Rubben H, Muller N, Siffert W: ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction. Urology. 2003 Jul;62(1):152-7. [PubMed:12837457 ]
PMID: 19289399
Sildenafil
Product: GSK180736A
Identifier : DBSNPE000031
Drug : DB00203 (Sildenafil)
Interacting Gene/Enzyme : Angiotensin-converting enzyme
Gene Name : ACE
UniProt ID : P12821
Defining Change(s) :
- Alu insertions (rs4646994 )
Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Better response to drug diveatment
References :
- Eisenhardt A, Sperling H, Hauck E, Porst H, Stief C, Rubben H, Muller N, Siffert W: ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction. Urology. 2003 Jul;62(1):152-7. [PubMed:12837457 ]
PMID: 17471175
Sildenafil
Product: Phytic acid
Identifier : DBSNPE000087
Drug : DB00203 (Sildenafil)
Interacting Gene/Enzyme : Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Gene Name : GNB3
UniProt ID : P16520
Allele Name : Not Available
Genotype(s) : (T;T) / (C;T)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Better response to drug diveatment
References :
- Sperling H, Eisenhardt A, Virchow S, Hauck E, Lenk S, Porst H, Stief C, Wetterauer U, Rubben H, Muller N, Siffert W: Sildenafil response is influenced by the G protein beta 3 subunit GNB3 C825T polymorphism: a pilot study. J Urol. 2003 Mar;169(3):1048-51. [PubMed:12576843 ]
PMID: 23607966
Sildenafil
Product: 1-Naphthaleneacetic acid
Identifier : DBSNPE000148
Drug : DB00203 (Sildenafil)
Interacting Gene/Enzyme : Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Gene Name : GNB3
UniProt ID : P16520
Allele Name : Not Available
Genotype(s) : (T;T)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Better response to drug diveatment. More patients experience a postive erectile response
References :
- Sperling H, Eisenhardt A, Virchow S, Hauck E, Lenk S, Porst H, Stief C, Wetterauer U, Rubben H, Muller N, Siffert W: Sildenafil response is influenced by the G protein beta 3 subunit GNB3 C825T polymorphism: a pilot study. J Urol. 2003 Mar;169(3):1048-51. [PubMed:12576843 ]
PMID: 24956278