Product Name :
AZD2098
Description:
AZD2098 is a potent and selective CC-chemokine receptor 4 (CCR4) inhibitor with pIC50s of 7.8, 8.0, 8.0 and 7.6 for human, rat, mouse and dog respectively, used for asthma research.
CAS:
566203-88-1
Molecular Weight:
334.18
Formula:
C11H9Cl2N3O3S
Chemical Name:
2,3-dichloro-N-(3-methoxypyrazin-2-yl)benzene-1-sulfonamide
Smiles :
COC1=NC=CN=C1NS(=O)(=O)C1=CC=CC(Cl)=C1Cl
InChiKey:
FLSMVCMSUNISFK-UHFFFAOYSA-N
InChi :
InChI=1S/C11H9Cl2N3O3S/c1-19-11-10(14-5-6-15-11)16-20(17,18)8-4-2-3-7(12)9(8)13/h2-6H,1H3,(H,14,16)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AZD2098 is a potent and selective CC-chemokine receptor 4 (CCR4) inhibitor with pIC50s of 7.8, 8.0, 8.0 and 7.6 for human, rat, mouse and dog respectively, used for asthma research.|Product information|CAS Number: 566203-88-1|Molecular Weight: 334.18|Formula: C11H9Cl2N3O3S|Chemical Name: 2,3-dichloro-N-(3-methoxypyrazin-2-yl)benzene-1-sulfonamide|Smiles: COC1=NC=CN=C1NS(=O)(=O)C1=CC=CC(Cl)=C1Cl|InChiKey: FLSMVCMSUNISFK-UHFFFAOYSA-N|InChi: InChI=1S/C11H9Cl2N3O3S/c1-19-11-10(14-5-6-15-11)16-20(17,18)8-4-2-3-7(12)9(8)13/h2-6H,1H3,(H,14,16)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (299.24 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.Rozanolixizumab In Vivo |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.Cediranib web |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AZD2098 potently inhibits chemokine-induced cellular responses, with pIC50 of 7.PMID:33370605 5 and 6.3 against CCL22-induced Ca2+ influx in hCCR4-expressing CHO cells and CCL17- or CCL22-induced chemotaxis of primary human Th2 cells respectively.|In Vivo:|AZD2098 (73.5-5.0 μg/kg; p.o.; BID; twice a day; 1 hour before and every 12 hours after antigen challenge) exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats, and the changes are first visible at a dose of 0.22 µmol/kg and maximal at 7.5 µmol/kg.|Products are for research use only. Not for human use.|