Product Name :
OTS514 hydrochloride
Description:
OTS514 hydrochloride is a highly potent TOPK inhibitor, which inhibits TOPK kinase activity with a median inhibitory concentration (IC50) value of 2.6 nM. OTS514 hydrochloride strongly suppresses the growth of TOPK-positive cancer cells. OTS514 hydrochloride induces cell cycle arrest and apoptosis.
CAS:
2319647-76-0
Molecular Weight:
400.92
Formula:
C21H21ClN2O2S
Chemical Name:
9-4-[(2R)-1-aminopropan-2-yl]phenyl-8-hydroxy-6-methyl-4H,5H-thieno[2,3-c]quinolin-4-one; chlorohydrogen
Smiles :
Cl.CC1=CC(O)=C(C2=C1NC(=O)C1SC=CC=12)C1C=CC(=CC=1)[C@@H](C)CN
InChiKey:
CQPRMBOOBXSZSP-YDALLXLXSA-N
InChi :
InChI=1S/C21H20N2O2S.ClH/c1-11-9-16(24)17(14-5-3-13(4-6-14)12(2)10-22)18-15-7-8-26-20(15)21(25)23-19(11)18;/h3-9,12,24H,10,22H2,1-2H3,(H,23,25);1H/t12-;/m0./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambien…
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Fulvestrant Technical Information
Additional information:
OTS514 hydrochloride is a highly potent TOPK inhibitor, which inhibits TOPK kinase activity with a median inhibitory concentration (IC50) value of 2.Citric acid site 6 nM.PMID:33157558 OTS514 hydrochloride strongly suppresses the growth of TOPK-positive cancer cells. OTS514 hydrochloride induces cell cycle arrest and apoptosis.|Product information|CAS Number: 2319647-76-0|Molecular Weight: 400.92|Formula: C21H21ClN2O2S|Chemical Name: 9-4-[(2R)-1-aminopropan-2-yl]phenyl-8-hydroxy-6-methyl-4H,5H-thieno[2,3-c]quinolin-4-one; chlorohydrogen|Smiles: Cl.CC1=CC(O)=C(C2=C1NC(=O)C1SC=CC=12)C1C=CC(=CC=1)[C@@H](C)CN|InChiKey: CQPRMBOOBXSZSP-YDALLXLXSA-N|InChi: InChI=1S/C21H20N2O2S.ClH/c1-11-9-16(24)17(14-5-3-13(4-6-14)12(2)10-22)18-15-7-8-26-20(15)21(25)23-19(11)18;/h3-9,12,24H,10,22H2,1-2H3,(H,23,25);1H/t12-;/m0./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: 10 mM in DMSO|Shipping Condition: Shipped under ambien…|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|OTS514 (1.5625-100 nM) induces cell cycle arrest and apoptosis at nanomolar concentrations in a series of human myeloma cell lines (HMCL) and prevents outgrowth of a putative CD138+ stem cell population from multiple myeloma (MM) patient-derived peripheral blood mononuclear cells.|In Vivo:|OTS514 (1-5 mg/kg; once a day for 2 weeks; intravenous administration) induces tumor regression in a xenograft model of A549 cells (TOPK-positive lung cancer cells).|References:|Kato T, et al. Oncotarget. 2016, 7(14):17652-64.Matsuo Y, et al. Sci Transl Med. 2014, 6(259):259ra145.Products are for research use only. Not for human use.|