Product Name :
8-Br-GTP
Description:
8-Br-GTP, a GTP analog, is a competitive FtsZ polymerization and GTPase activity (Ki of 31.8 μM) inhibitor. 8-Br-GTP can be used for nucleic acid modification.
CAS:
23197-98-0
Molecular Weight:
602.08
Formula:
C10H15BrN5O14P3
Chemical Name:
([([(2R,3S,4R,5R)-5-(2-amino-8-bromo-6-oxo-6,9-dihydro-3H-purin-9-yl)-5-hydrogenio-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl)oxy](hydroxy)phosphoryloxy)phosphonic acid
Smiles :
NC1NC2=C(N=C(Br)N2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N=1
InChiKey:
CNYUHYBBHQMZQJ-UMMCILCDSA-N
InChi :
InChI=1S/C10H15BrN5O14P3/c11-9-13-3-6(14-10(12)15-7(3)19)16(9)8-5(18)4(17)2(28-8)1-27-32(23,24)30-33(25,26)29-31(20,21)22/h2,4-5,8,17-18H,1H2,(H,23,24)(H,25,26)(H2,20,21,22)(H3,12,14,15,19)/t2-,4-,5-,8-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
8-Br-GTP, a GTP analog, is a competitive FtsZ polymerization and GTPase activity (Ki of 31.8 μM) inhibitor. 8-Br-GTP can be used for nucleic acid modification.|Product information|CAS Number: 23197-98-0|Molecular Weight: 602.08|Formula: C10H15BrN5O14P3|Chemical Name: ([([(2R,3S,4R,5R)-5-(2-amino-8-bromo-6-oxo-6,9-dihydro-3H-purin-9-yl)-5-hydrogenio-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl)oxy](hydroxy)phosphoryloxy)phosphonic acid|Smiles: NC1NC2=C(N=C(Br)N2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N=1|InChiKey: CNYUHYBBHQMZQJ-UMMCILCDSA-N|InChi: InChI=1S/C10H15BrN5O14P3/c11-9-13-3-6(14-10(12)15-7(3)19)16(9)8-5(18)4(17)2(28-8)1-27-32(23,24)30-33(25,26)29-31(20,21)22/h2,4-5,8,17-18H,1H2,(H,23,24)(H,25,26)(H2,20,21,22)(H3,12,14,15,19)/t2-,4-,5-,8-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Gabapentin MedChemExpress |Shelf Life: ≥12 months if stored properly.Cholestyramine Epigenetic Reader Domain |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:31608712 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|8-Br-GTP inhibits FtsZ polymerization but does not affect tubulin polymerization.8-Br-GTP has two stable orientations of the base toward the sugar: anti and syn. 8-Br-GTP shows preference for the syn conformation (population ~90%).|References:|Tilman Läppchen, et al. GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin. Biochemistry. 2005 May 31;44(21):7879-84.Jozef Hritz, et al. Optimization of replica exchange molecular dynamics by fast mimicking. J Chem Phys. 2007 Nov 28;127(20):204104.Products are for research use only. Not for human use.|