Product Name :
IQ-3
Description:
IQ-3 is a specific inhibitor of the c-Jun N-terminal kinase (JNK) family, with preference for JNK3. IQ-3 exhibits Kd values of 0.24 μM, 0.29 μM and 0.066 μM for JNK1, JNK2 and JNK3, respectively.
CAS:
312538-03-7
Molecular Weight:
341.32
Formula:
C20H11N3O3
Chemical Name:
[(11E)-11H-indeno[1, 2-b]quinoxalin-11-ylidene]amino furan-2-carboxylate
Smiles :
O=C(O/N=C1/C2=NC3=CC=CC=C3N=C2C2=CC=CC=C2/1)C1=CC=CO1
InChiKey:
WBSWWONMTZEOGS-PTGBLXJZSA-N
InChi :
InChI=1S/C20H11N3O3/c24-20(16-10-5-11-25-16)26-23-18-13-7-2-1-6-12(13)17-19(18)22-15-9-4-3-8-14(15)21-17/h1-11H/b23-18+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
IQ-3 is a specific inhibitor of the c-Jun N-terminal kinase (JNK) family, with preference for JNK3.{{Verubecestat} MedChemExpress|{Verubecestat} Neuronal Signaling|{Verubecestat} Epigenetics|{Verubecestat} Biological Activity|{Verubecestat} References|{Verubecestat} manufacturer} IQ-3 exhibits Kd values of 0.{{Beta Actin Mouse mAb} medchemexpress|{Beta Actin Mouse mAb} Technical Information|{Beta Actin Mouse mAb} Formula|{Beta Actin Mouse mAb} manufacturer|{Beta Actin Mouse mAb} Cancer} 24 μM, 0.29 μM and 0.066 μM for JNK1, JNK2 and JNK3, respectively.|Product information|CAS Number: 312538-03-7|Molecular Weight: 341.32|Formula: C20H11N3O3|Chemical Name: [(11E)-11H-indeno[1, 2-b]quinoxalin-11-ylidene]amino furan-2-carboxylate|Smiles: O=C(O/N=C1/C2=NC3=CC=CC=C3N=C2C2=CC=CC=C2/1)C1=CC=CO1|InChiKey: WBSWWONMTZEOGS-PTGBLXJZSA-N|InChi: InChI=1S/C20H11N3O3/c24-20(16-10-5-11-25-16)26-23-18-13-7-2-1-6-12(13)17-19(18)22-15-9-4-3-8-14(15)21-17/h1-11H/b23-18+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (73.PMID:33096002 25 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|IQ-3 exhibits IC50 of 2.2 μM (TNF-α in human monoMac-6 cells), 1.5 μM (IL-6 in human monoMac-6 cells), 4.7 μM (TNF-α in human PBMCs), 9.1 μM (IL-6 in human PBMCs) and 6.1 μM (NO in murine J774.A1), respectively. IQ-3 exhibits an IC50 of 1.4 μM for inhibiting LPS-induced NF-κB/AP-1 transcriptional activity in human THP-1 Blue monocytic cells. IQ-3 is indeed a competitive inhibitor for the ATP binding site of JNK3.|References:|Igor A Schepetkin, et al. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol. 2012 Jun;81(6):832-45.Products are for research use only. Not for human use.|