MG-132

Description:
Key inhibitor for use in proteasome research. High purity peptide Most economical MG-132 on the market Widely cited for more than two decades Well-characterized with a variety of applications MG-132 is a potent, cell permeable and selective proteasome inhibitor (Ki = 4nM).{{2270879-17-7} web|{2270879-17-7} Protocol|{2270879-17-7} Data Sheet|{2270879-17-7} supplier} 1 It inhibits NF-κB activation by preventing IκB degradation (IC50 = 3μM). The peptide blocks degradation of short-lived proteins, which in turn induces HSP and ER chaperone expression, leading to thermotolerance (1μM MG-132, 2 h.). It also stimulates neurite outgrowth in PC12 cells (20nM optimal). The peptide has also been reported to increase the survival rate of mesenchymal stem cells following their transplantation. IC50’s for inhibition of Suc-LLVY-AMC and Z-LLL-AMC cleaving activities of proteasome were 0.85 and 0.1μM respectively. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-132 activates autophagy.{{1931944-80-7} web|{1931944-80-7} Protocol|{1931944-80-7} Formula|{1931944-80-7} custom synthesis}