Product Name :
BRD3308
CAS No.:
1550053-02-5
Purity :
98.82%
Shipping:
Room temperature in the continental U.S. Other areas may vary.
Storage :
Powder: -20°C, 3 years; 4°C, 2 yearsIn solvent: -80°C, 6 months; -20°C, 1 month
SMILES:
O=C(C)NC1=CC=C(C(NC2=CC=C(F)C=C2N)=O)C=C1
Product Description :
BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM.{{2760483-96-1} web|{2760483-96-1} Biological Activity|{2760483-96-1} References|{2760483-96-1} manufacturer} BRD3308 is 23-fold selectivity for HDAC3 over HDAC1 (IC50 of 1.26 μM) or HDAC2 (IC50 of 1.34 μM). BRD3308 suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release. BRD3308 activates HIV-1 transcription and disrupts HIV-1 latency.
Formula:
C15H14FN3O2
Molecular Weight :
287.29
Synonyms:
Additional Information:
|CAS No. 1550053-02-5 ; |Formula C15H14FN3O2 ; |Molecular Weight 287.{{796073-69-3} MedChemExpress|{796073-69-3} Biological Activity|{796073-69-3} In stock|{796073-69-3} custom synthesis} 29 ; |SMILES O=C(C)NC1=CC=C(C(NC2=CC=C(F)C=C2N)=O)C=C1 ; |Target HDAC, HIV, Apoptosis ; |Product Description BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM.PMID:25905286 BRD3308 is 23-fold selectivity for HDAC3 over HDAC1 (IC50 of 1.26 μM) or HDAC2 (IC50 of 1.34 μM). BRD3308 suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release. BRD3308 activates HIV-1 transcription and disrupts HIV-1 latency. ; |Format Solid ; |Color Off-white to light yellow ; |Purity 98.82% ; |Shipping Room temperature in the continental U.S. Other areas may vary. ; |Storage Powder: -20°C, 3 years; 4°C, 2 yearsIn solvent: -80°C, 6 months; -20°C, 1 month ; |Solubility Overview Soluble in DMSO