Product Name :
Posaconazole
Description:
Posaconazole is a triazole antifungal drug marketed in the United States by Schering-Plough under the trade name Noxafil. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase.
CAS:
171228-49-2
Molecular Weight:
700.78
Formula:
C37H42F2N8O4
Chemical Name:
4-[4-[4-[4-[[(3R, 5R)-5-(2, 4-difluorophenyl)-5-(1, 2, 4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S, 3S)-2-hydroxypentan-3-yl]-1, 2, 4-triazol-3-one
Smiles :
C[C@H](O)[C@H](CC)N1N=CN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(C=C1)OC[C@H]1C[C@@](CN2C=NC=N2)(OC1)C1=CC=C(F)C=C1F
InChiKey:
RAGOYPUPXAKGKH-XAKZXMRKSA-N
InChi :
InChI=1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Posaconazole is a triazole antifungal drug marketed in the United States by Schering-Plough under the trade name Noxafil. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase.|Product information|CAS Number: 171228-49-2|Molecular Weight: 700.78|Formula: C37H42F2N8O4|Synonym:|Noxafil|SCH-56592|Schering 56592|Sch 56592|Chemical Name: 4-[4-[4-[4-[[(3R, 5R)-5-(2, 4-difluorophenyl)-5-(1, 2, 4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S, 3S)-2-hydroxypentan-3-yl]-1, 2, 4-triazol-3-one|Smiles: C[C@H](O)[C@H](CC)N1N=CN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(C=C1)OC[C@H]1C[C@@](CN2C=NC=N2)(OC1)C1=CC=C(F)C=C1F|InChiKey: RAGOYPUPXAKGKH-XAKZXMRKSA-N|InChi: InChI=1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Pretomanid} MedChemExpress|{Pretomanid} Anti-infection|{Pretomanid} Biological Activity|{Pretomanid} Description|{Pretomanid} custom synthesis|{Pretomanid} Cancer} |Shelf Life: ≥12 months if stored properly.{{DNQX} medchemexpress|{DNQX} Membrane Transporter/Ion Channel|{DNQX} Immunology/Inflammation|{DNQX} Technical Information|{DNQX} In stock|{DNQX} supplier} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23710097 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|