Product Name :
FIDAS-5
Description:
FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities.
CAS:
1391934-98-7
Molecular Weight:
261.72
Formula:
C15H13ClFN
Chemical Name:
FIDAS-5
Smiles :
CNC1C=CC(/C=C/C2=C(F)C=CC=C2Cl)=CC=1
InChiKey:
KXVXICBOMOGFMH-JXMROGBWSA-N
InChi :
InChI=1S/C15H13ClFN/c1-18-12-8-5-11(6-9-12)7-10-13-14(16)3-2-4-15(13)17/h2-10,18H,1H3/b10-7+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Inclisiran} site|{Inclisiran} Small Interfering RNA (siRNA)|{Inclisiran} Protocol|{Inclisiran} Description|{Inclisiran} manufacturer|{Inclisiran} Epigenetics}
Additional information:
FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding.{{Laccaic acid A} medchemexpress|{Laccaic acid A} Cell Cycle/DNA Damage|{Laccaic acid A} Biological Activity|{Laccaic acid A} References|{Laccaic acid A} custom synthesis|{Laccaic acid A} Epigenetics} FIDAS-5 has anticancer activities.PMID:23618405 |Product information|CAS Number: 1391934-98-7|Molecular Weight: 261.72|Formula: C15H13ClFN|Chemical Name: FIDAS-5|Smiles: CNC1C=CC(/C=C/C2=C(F)C=CC=C2Cl)=CC=1|InChiKey: KXVXICBOMOGFMH-JXMROGBWSA-N|InChi: InChI=1S/C15H13ClFN/c1-18-12-8-5-11(6-9-12)7-10-13-14(16)3-2-4-15(13)17/h2-10,18H,1H3/b10-7+|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 125 mg/mL (477.61 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|FIDAS-5 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells. FIDAS-5 (3 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. And FIDAS-5 induces the expression of cell cycle inhibitor, p21WAF1/CIP1. FIDAS-5 (3 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells.|In Vivo:|FIDAS-5 (20 mg/kg; oral gavage; daily; for two weeks; athymic nude mice) treatment significantly inhibits the growth of xenograft tumors, with minimal difference in body weight. Mice are treated with FIDAS-5 (20 mg/kg) for 1 week. The liver SAM levels are significantly reduced.|References:|Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes repress colon cancer bytargeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8(4):796-803.Products are for research use only. Not for human use.|