Product Name :
AZ9482
Description:
AZ9482 is a triple PARP1/2/6 inhibitor, with IC50 values of 1 nM, 1 nM and 640 nM for PARP1, PARP2 and PARP6, respectively.
CAS:
1825345-33-2
Molecular Weight:
450.49
Formula:
C26H22N6O2
Chemical Name:
2-(4-{3-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoyl}piperazin-1-yl)pyridine-3-carbonitrile
Smiles :
N#CC1=CC=CN=C1N1CCN(CC1)C(=O)C1=CC(CC2=NNC(=O)C3=CC=CC=C23)=CC=C1
InChiKey:
ZDDPBFWHZOJFHF-UHFFFAOYSA-N
InChi :
InChI=1S/C26H22N6O2/c27-17-20-7-4-10-28-24(20)31-11-13-32(14-12-31)26(34)19-6-3-5-18(15-19)16-23-21-8-1-2-9-22(21)25(33)30-29-23/h1-10,15H,11-14,16H2,(H,30,33)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Hispidin} web|{Hispidin} Epigenetics|{Hispidin} Technical Information|{Hispidin} Data Sheet|{Hispidin} custom synthesis|{Hispidin} Cancer}
Shelf Life:
≥12 months if stored properly.{{Butylphthalide} MedChemExpress|{Butylphthalide} Protocol|{Butylphthalide} Data Sheet|{Butylphthalide} manufacturer|{Butylphthalide} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32180353
Additional information:
AZ9482 is a triple PARP1/2/6 inhibitor, with IC50 values of 1 nM, 1 nM and 640 nM for PARP1, PARP2 and PARP6, respectively.|Product information|CAS Number: 1825345-33-2|Molecular Weight: 450.49|Formula: C26H22N6O2|Chemical Name: 2-(4-{3-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoyl}piperazin-1-yl)pyridine-3-carbonitrile|Smiles: N#CC1=CC=CN=C1N1CCN(CC1)C(=O)C1=CC(CC2=NNC(=O)C3=CC=CC=C23)=CC=C1|InChiKey: ZDDPBFWHZOJFHF-UHFFFAOYSA-N|InChi: InChI=1S/C26H22N6O2/c27-17-20-7-4-10-28-24(20)31-11-13-32(14-12-31)26(34)19-6-3-5-18(15-19)16-23-21-8-1-2-9-22(21)25(33)30-29-23/h1-10,15H,11-14,16H2,(H,30,33)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (277.48 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AZ9482 exhibits an EC50 of 24 nM in MDA-MB-468 cells. AZ0108 treatment prevents CHK1 MARylation and induces hyperphosphorylation of CHK1, contributing to MPS formation and dysregulation of the cell cycle.|In Vivo:|AZ0108 also displays toxicity in vivo, the molecular basis of which is currently undefined, limiting pharmacological evaluation of AZ0108.|Products are for research use only. Not for human use.|