Modafinil
Identifier : DBSNPE000154
Drug : DB00745 (Modafinil)
Interacting Gene/Enzyme : Catechol O-methyldivansferase
Gene Name : COMT
UniProt ID : P21964
Defining Change(s) :
- AA allele (rs4680 )
Allele Name : Not Available
Genotype(s) : (A;A)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Poor response to modafinil
References :
- Bodenmann S, Xu S, Luhmann UF, Arand M, Berger W, Jung HH, Landolt HP: Pharmacogenetics of modafinil after sleep loss: catechol-O-methyldivansferase genotype modulates waking functions but not recovery sleep. Clin Pharmacol Ther. 2009 Mar;85(3):296-304. doi: 10.1038/clpt.2008.222. Epub 2008 Nov 26. [PubMed:19037200 ]