Cyclophosphamide
Identifier : DBSNPE000141
Drug : DB00531 (Cyclophosphamide)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :
- G Allelle (rs2740574 )
Allele Name : CYP3A4*1B
Genotype(s) : (G;G) / (A;G)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Decreased activation of cyclophosphamide most likely condivibuting to worse disease free survival in adjuvant chemotherapy for node-positive breast cancer
References :
- Gor PP, Su HI, Gray RJ, Gimotty PA, Horn M, Aplenc R, Vaughan WP, Tallman MS, Rebbeck TR, DeMichele A: Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a redivospective cohort study. Breast Cancer Res. 2010;12(3):R26. doi: 10.1186/bcr2570. Epub 2010 May 10. [PubMed:20459744 ]