PI3KInhibitorpi3kinhibitor

Gefitinib

By

Gefitinib

Product: Celgosivir (hydrochloride)

Identifier : DBSNPE000138
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : ATP-binding cassette sub-family G member 2
Gene Name : ABCG2
UniProt ID : Q9UNQ0
Defining Change(s) :

  • A allele (rs2231142 )

Allele Name : Not Available
Genotype(s) : (A;C)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : In non-small lung cancer patients, those that are heterozygous (ABCG2 421C>A) have a higher risk of diarrhea.
References :

  1. Cusatis G, Gregorc V, Li J, Spreafico A, Ingersoll RG, Verweij J, Ludovini V, Villa E, Hidalgo M, Sparreboom A, Baker SD: Pharmacogenetics of ABCG2 and adverse reactions to gefitinib. J Natl Cancer Inst. 2006 Dec 6;98(23):1739-42. [PubMed:17148776 ]

PMID: 20631885

Gefitinib

By

Gefitinib

Product: Saroglitazar (Magnesium)

Identifier : DBSNPE000163
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Epidermal growth factor receptor
Gene Name : EGFR
UniProt ID : P00533
Defining Change(s) :

  • T > G (rs121434568 )

Allele Name : L858R
Genotype(s) : (G;G) / (G;T)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Associated with enhanced activation of the EGFR tyrosine kinase in patients with non-small cell lung cancer (NSCLC) recieving tyrosine kinase inhibitor therapy.
References :

  1. Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. Epub 2004 Apr 29. [PubMed:15118073 ]

PMID: 25548285

Gefitinib

By

Gefitinib

Product: Bay 41-4109 (racemate)

Identifier : DBSNPE000199
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Epidermal growth factor receptor
Gene Name : EGFR
UniProt ID : P00533
Defining Change(s) :

  • G > A or C or T (rs28929495 )

Allele Name : G719A/C
Genotype(s) : (T;T) / (G;T) / (A;A) / (A;G) / (C;C) / (C;G)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Associated with enhanced activation of the EGFR tyrosine kinase in patients with non-small cell lung cancer (NSCLC) recieving tyrosine kinase inhibitor therapy.
References :

  1. Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. Epub 2004 Apr 29. [PubMed:15118073 ]

PMID: 21949864

Gefitinib

By

Gefitinib

Product: Mutagenic Impurity of Tenofovir Disoproxil

Identifier : DBSNPE000204
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Epidermal growth factor receptor
Gene Name : EGFR
UniProt ID : P00533
Defining Change(s) :

  • T > A or G (rs121913444 )

Allele Name : L861Q
Genotype(s) : (A;A) / (A;T) / (G;G) / (G;T)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Associated with enhanced activation of the EGFR tyrosine kinase in patients with non-small cell lung cancer (NSCLC) recieving tyrosine kinase inhibitor therapy.
References :

  1. Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. Epub 2004 Apr 29. [PubMed:15118073 ]

PMID: 17467171

Gefitinib

By

Gefitinib

Product: Adapalene (sodium salt)

Identifier : DBSNPE004639
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs35742686 )

Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 23773140

Gefitinib

By

Gefitinib

Product: Adapalene

Identifier : DBSNPE004640
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs3892097 )

Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 20605904

Gefitinib

By

Gefitinib

Product: Acarbose (sulfate)

Identifier : DBSNPE004641
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Whole-gene deletion

Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 19371629

Gefitinib

By

Gefitinib

Product: Acarbose

Identifier : DBSNPE004642
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1707delT (rs5030655 )

Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 16118208

Gefitinib

By

Gefitinib

Product: Prasugrel (Maleic acid)

Identifier : DBSNPE004643
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2935A>C (rs5030867 )

Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 24131448

Gefitinib

By

Gefitinib

Product: Prasugrel (hydrochloride)

Identifier : DBSNPE004644
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>T (rs5030865 )

Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 23562243

Gefitinib

By

Gefitinib

Product: Posaconazole (hydrate)

Identifier : DBSNPE004645
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 883G>C (rs5030863 )

Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 23592516

Gefitinib

By

Gefitinib

Product: Entecavir (monohydrate)

Identifier : DBSNPE004646
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 124G>A (rs5030862 )

Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 18418891

Gefitinib

By

Gefitinib

Product: Dienogest

Identifier : DBSNPE004647
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • CYP2D7/2D6 hybrid gene sdivucture

Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 17668877

Gefitinib

By

Gefitinib

Product: Leflunomide

Identifier : DBSNPE004648
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>A (rs5030865 )

Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 17854798

Gefitinib

By

Gefitinib

Product: Agomelatine (L(+)-Tartaric acid)

Identifier : DBSNPE004649
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 137insT, 137_138insT

Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 26459563

Gefitinib

By

Gefitinib

Product: Agomelatine (hydrochloride)

Identifier : DBSNPE004650
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2539_2542delAACT (rs72549353 )

Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 22582137

Gefitinib

By

Gefitinib

Product: Vincristine (sulfate)

Identifier : DBSNPE004651
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1973_1974insG (rs72549354 )

Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 8528578

Gefitinib

By

Gefitinib

Product: Folinic acid (calcium salt pentahydrate)

Identifier : DBSNPE004652
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2573insC

Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 7813579

Gefitinib

By

Gefitinib

Product: Letrozole

Identifier : DBSNPE004653
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1770G>A
  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 310G>T
  • 746C>G
  • 843T>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4042G>A
  • 4180G>C
  • 4481G>A

Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 8422387

Gefitinib

By

Gefitinib

Product: Raloxifene (hydrochloride)

Identifier : DBSNPE004654
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • variable number of A’s in the region -1258 to -1237a
  • -1235A>G
  • -1000G>A
  • 1039C>T
  • 1661G>C
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 24710004

Gefitinib

By

Gefitinib

Product: Etoposide

Identifier : DBSNPE004655
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2587_2590delGACT (rs72549351 )

Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 22802704

Gefitinib

By

Gefitinib

Product: Epirubicin (hydrochloride)

Identifier : DBSNPE004656
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1863_1864ins(TTT CGC CCC)2 (rs72549356 )

Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 20889759

Gefitinib

By

Gefitinib

Product: Dacarbazine

Identifier : DBSNPE004657
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3259_3260insGT (rs72549346 )

Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 20574537

Gefitinib

By

Gefitinib

Product: Bendamustine (hydrochloride)

Identifier : DBSNPE004658
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2950G>C

Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 20351057

Gefitinib

By

Gefitinib

Product: (±)-Bisoprolol (hemifumarate)

Identifier : DBSNPE004659
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 73C<T
  • 1039C>T
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 21461354

Gefitinib

By

Gefitinib

Product: Melatonin

Identifier : DBSNPE004660
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 1661G>C
  • 2850C>T
  • 3172A>C
  • 4180G>C

Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 7851504

Gefitinib

By

Gefitinib

Product: Finasteride (acetate)

Identifier : DBSNPE004661
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3201C>T (rs72549347 )

Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 7510950

Gefitinib

By

Gefitinib

Product: Finasteride

Identifier : DBSNPE004662
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T
  • 310G>T
  • 843T>G
  • 887C>T
  • 1039C>T
  • 1661G>C
  • 3384A>C
  • 3582A>G
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 7535234

Gefitinib

By

Gefitinib

Product: Exemestane

Identifier : DBSNPE004663
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 4044C>T

Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 8832069

Gefitinib

By

Gefitinib

Product: Valproic acid

Identifier : DBSNPE004664
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • CYP2D7 sequence from indivon 1 onwards

Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 23261866

Gefitinib

By

Gefitinib

Product: Valproic acid (sodium salt)

Identifier : DBSNPE004665
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.

Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 23690783

Gefitinib

By

Gefitinib

Product: Cisplatin

Identifier : DBSNPE004666
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 746C>G
  • 843T>G
  • 1062A>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4180G>C
  • 4401C>T
  • 4481G>A

Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 19657070

Gefitinib

By

Gefitinib

Product: GDC-0032

Identifier : DBSNPE004667
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1995delC

Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 8884206

Gefitinib

By

Gefitinib

Product: LY2334737

Identifier : DBSNPE004668
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1109C>T
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2828delC
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 7533610

Gefitinib

By

Gefitinib

Product: RN486

Identifier : DBSNPE004669
Drug : DB00317 (Gefitinib)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2927_2945delGATCCTACATCCGGATGTG
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer.
References :

  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AsdivaZeneca Pharmaceuticals LP; 2015. [Link]

PMID: 7693279

By

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