Amiodarone
Identifier : DBSNPE000135
Drug : DB01118 (Amiodarone)
Interacting Gene/Enzyme : Potassium voltage-gated channel subfamily H member 2
Gene Name : KCNH2
UniProt ID : Q12809
Defining Change(s) :
- KCNE2
Allele Name : MiRP1
Genotype(s) : Not Available
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Channels formed with mutant MiRP1 subunits and HERG showed slower activation, faster deactivation, and increased drug sensitivity and is associated with cardiac arrhythmia.
References :
- Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA: MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 1999 Apr 16;97(2):175-87. [PubMed:10219239 ]