Abacavir
Identifier : DBSNPE000129
Drug : DB01048 (Abacavir)
Interacting Gene/Enzyme : HLA class I histocompatibility antigen protein P5
Gene Name : HCP5
UniProt ID : Q6MZN7
Defining Change(s) :
- G allele (rs2395029 )
Allele Name : HLA-B*5701
Genotype(s) : (G;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Presence of this SNP is predicative of hypersenitivity reaction when abacavir is given to HIV+ patients.
References :
- Colombo S, Rauch A, Rotger M, Fellay J, Martinez R, Fux C, Thurnheer C, Gunthard HF, Goldstein DB, Furrer H, Telenti A: The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir. J Infect Dis. 2008 Sep 15;198(6):864-7. doi: 10.1086/591184. [PubMed:18684101 ]
- Daly AK, Donaldson PT, Bhatnagar P, Shen Y, Peer I, Floratos A, Daly MJ, Goldstein DB, John S, Nelson MR, Graham J, Park BK, Dillon JF, Bernal W, Cordell HJ, Pirmohamed M, Aithal GP, Day CP: HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet. 2009 Jul;41(7):816-9. doi: 10.1038/ng.379. Epub 2009 May 31. [PubMed:19483685 ]