Clozapine
Identifier : DBSNPE000128
Drug : DB00363 (Clozapine)
Interacting Gene/Enzyme : Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Gene Name : GNB3
UniProt ID : P16520
Defining Change(s) :
- TT allele (rs5443 )
Allele Name : Not Available
Genotype(s) : (T;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Schizophrenia patients taking this drug gain more weight than patients with at least one rs5443(c) allele
References :
- Wang YC, Bai YM, Chen JY, Lin CC, Lai IC, Liou YJ: C825T polymorphism in the human G protein beta3 subunit gene is associated with long-term clozapine diveatment-induced body weight change in the Chinese population. Pharmacogenet Genomics. 2005 Oct;15(10):743-8. [PubMed:16141801 ]