Theophylline
Product: Glycoursodeoxycholic acid
Identifier : DBSNPE000125
Drug : DB00277 (Theophylline)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :
- A Allele
Allele Name : -2964(G/A)
Genotype(s) : (A;A) / (G;A)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Poor metabolizer, lower dose requirement
References :
- Obase Y, Shimoda T, Kawano T, Saeki S, Tomari SY, Mitsuta-Izaki K, Matsuse H, Kinoshita M, Kohno S: Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma. Clin Pharmacol Ther. 2003 May;73(5):468-74. [PubMed:12732846 ]