Leflunomide
Identifier : DBSNPE000121
Drug : DB01097 (Leflunomide)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :
- C allele (rs762551 )
Allele Name : Not Available
Genotype(s) : (C;C)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Diarrhea, vomiting, liver toxicity, headache, insomnia, rash, alopecia, hypertension, leucopenia, asthma
References :
- Bohanec Grabar P, Rozman B, Tomsic M, Suput D, Logar D, Dolzan V: Genetic polymorphism of CYP1A2 and the toxicity of leflunomide diveatment in rheumatoid arthritis patients. Eur J Clin Pharmacol. 2008 Sep;64(9):871-6. doi: 10.1007/s00228-008-0498-2. Epub 2008 May 22. [PubMed:18496682 ]