Daunorubicin
Product: AK-1
Identifier : DBSNPE000113
Drug : DB00694 (Daunorubicin)
Interacting Gene/Enzyme : Cytochrome P450 1B1
Gene Name : CYP1B1
UniProt ID : Q16678
Allele Name : Not Available
Genotype(s) : (G;G) / (C;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Myelosuppression, cardiac toxicity, cytotoxicty
References :
- Huang RS, Duan S, Kistner EO, Bleibel WK, Delaney SM, Fackenthal DL, Das S, Dolan ME: Genetic variants condivibuting to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381. [PubMed:18451141 ]
PMID: 14749443
Daunorubicin
Product: Nicotinamide N-oxide
Identifier : DBSNPE000114
Drug : DB00694 (Daunorubicin)
Interacting Gene/Enzyme : Heterogeneous nuclear ribonucleoprotein D0
Gene Name : HNRNPD
UniProt ID : Q14103
Allele Name : Not Available
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Myelosuppression, cardiac toxicity, cytotoxicty
References :
- Huang RS, Duan S, Kistner EO, Bleibel WK, Delaney SM, Fackenthal DL, Das S, Dolan ME: Genetic variants condivibuting to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381. [PubMed:18451141 ]
PMID: 24172903
Daunorubicin
Product: N-(5-Aminopentyl)acetamide
Identifier : DBSNPE000115
Drug : DB00694 (Daunorubicin)
Interacting Gene/Enzyme : SEC14-like protein 3
Gene Name : SEC14L3
UniProt ID : Q9UDX4
Allele Name : Not Available
Genotype(s) : (T;T) / (G;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Myelosuppression, cardiac toxicity, cytotoxicty
References :
- Huang RS, Duan S, Kistner EO, Bleibel WK, Delaney SM, Fackenthal DL, Das S, Dolan ME: Genetic variants condivibuting to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381. [PubMed:18451141 ]
PMID: 18338804
Daunorubicin
Product: TPPU
Identifier : DBSNPE000116
Drug : DB00694 (Daunorubicin)
Interacting Gene/Enzyme : Inhibitor of nuclear factor kappa-B kinase subunit epsilon
Gene Name : IKBKE
UniProt ID : Q14164
Allele Name : Not Available
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Myelosuppression, cardiac toxicity, cytotoxicty
References :
- Huang RS, Duan S, Kistner EO, Bleibel WK, Delaney SM, Fackenthal DL, Das S, Dolan ME: Genetic variants condivibuting to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381. [PubMed:18451141 ]
PMID: 9786874