Carbamazepine
Product: L-DABA
Identifier : DBSNPE000101
Drug : DB00564 (Carbamazepine)
Interacting Gene/Enzyme : Heat shock 70 kDa protein 1-like
Gene Name : HSPA1L
UniProt ID : P34931
Allele Name : Not Available
Genotype(s) : (T;T) / (C;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Hypersensitivity reaction, mild erythematous skin rashes, macropapular eruption, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis
References :
- Alfirevic A, Mills T, Harrington P, Pinel T, Sherwood J, Jawaid A, Smith JC, March RE, Barratt BJ, Chadwick DW, Kevin Park B, Pirmohamed M: Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006 Apr;16(4):287-96. [PubMed:16538175 ]
PMID: 22010199
Carbamazepine
Product: Vanilpyruvic acid
Identifier : DBSNPE000102
Drug : DB00564 (Carbamazepine)
Interacting Gene/Enzyme : Heat shock 70 kDa protein 1A/1B
Gene Name : HSPA1A
UniProt ID : P08107
Allele Name : Not Available
Genotype(s) : (C;C) / (C;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Hypersensitivity reaction, mild erythematous skin rashes, macropapular eruption, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis
References :
- Alfirevic A, Mills T, Harrington P, Pinel T, Sherwood J, Jawaid A, Smith JC, March RE, Barratt BJ, Chadwick DW, Kevin Park B, Pirmohamed M: Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006 Apr;16(4):287-96. [PubMed:16538175 ]
PMID: 20855151
Carbamazepine
Product: Lurbinectedin
Identifier : DBSNPE000103
Drug : DB00564 (Carbamazepine)
Interacting Gene/Enzyme : Heat shock 70 kDa protein 1A/1B
Gene Name : HSPA1A
UniProt ID : P08107
Allele Name : Not Available
Genotype(s) : (C;C) / (C;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Hypersensitivity reaction, mild erythematous skin rashes, macropapular eruption, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis
References :
- Alfirevic A, Mills T, Harrington P, Pinel T, Sherwood J, Jawaid A, Smith JC, March RE, Barratt BJ, Chadwick DW, Kevin Park B, Pirmohamed M: Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006 Apr;16(4):287-96. [PubMed:16538175 ]
PMID: 20471392
Carbamazepine
Product: Olcegepant (hydrochloride)
Identifier : DBSNPE000104
Drug : DB00564 (Carbamazepine)
Interacting Gene/Enzyme : HLA class I histocompatibility antigen, B-15 alpha chain
Gene Name : HLA-B
UniProt ID : P30464
Allele Name : Not Available
Genotype(s) : (T;T) / (G;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis
References :
- Hung SI, Chung WH, Jee SH, Chen WC, Chang YT, Lee WR, Hu SL, Wu MT, Chen GS, Wong TW, Hsiao PF, Chen WH, Shih HY, Fang WH, Wei CY, Lou YH, Huang YL, Lin JJ, Chen YT: Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics. 2006 Apr;16(4):297-306. [PubMed:16538176 ]
PMID: 20154358
Carbamazepine
Product: Thyroxine sulfate
Identifier : DBSNPE000105
Drug : DB00564 (Carbamazepine)
Interacting Gene/Enzyme : HLA class I histocompatibility antigen, A-31 alpha chain
Gene Name : HLA-A
UniProt ID : P16189
Allele Name : Not Available
Genotype(s) : (G;G) / (C;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Macropapular eruption
References :
- Hung SI, Chung WH, Jee SH, Chen WC, Chang YT, Lee WR, Hu SL, Wu MT, Chen GS, Wong TW, Hsiao PF, Chen WH, Shih HY, Fang WH, Wei CY, Lou YH, Huang YL, Lin JJ, Chen YT: Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics. 2006 Apr;16(4):297-306. [PubMed:16538176 ]
PMID: 20412391
Carbamazepine
Product: Glycochenodeoxycholic acid
Identifier : DBSNPE000106
Drug : DB00564 (Carbamazepine)
Interacting Gene/Enzyme : Promotilin
Gene Name : MLN
UniProt ID : P12872
Allele Name : Not Available
Genotype(s) : (A;A) / (A;C)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Hypersensitivity syndrome
References :
- Hung SI, Chung WH, Jee SH, Chen WC, Chang YT, Lee WR, Hu SL, Wu MT, Chen GS, Wong TW, Hsiao PF, Chen WH, Shih HY, Fang WH, Wei CY, Lou YH, Huang YL, Lin JJ, Chen YT: Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics. 2006 Apr;16(4):297-306. [PubMed:16538176 ]
PMID: 20144602
Carbamazepine
Product: Batefenterol
Identifier : DBSNPE000143
Drug : DB00564 (Carbamazepine)
Interacting Gene/Enzyme : Sodium channel protein type 1 subunit alpha
Gene Name : SCN1A
UniProt ID : P35498
Defining Change(s) :
- IVS5N + 5 G>A (rs3812718 )
Allele Name : Not Available
Genotype(s) : (A;A) / (A;G)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Carbamazepine resistant therapy, higher maintenance dose
References :
- Sterjev Z, Kiteva G, Cvetkovska E, Pedivov I, Kuzmanovski I, Ribarska T, Nestorovska K, Matevska N, Trajkovik-Jolevska S, Dimovski A, Suturkova Lj: Influence of the SCN1A IVS5N + 5 G>A Polymorphism on Therapy with Carbamazepine for Epilepsy. Balkan J Med Genet. 2012 Jun;15(1):19-24. doi: 10.2478/v10034-012-0003-1. [PubMed:24052718 ]
PMID: 9753474
Carbamazepine
Product: Sodium ionophore III
Identifier : DBSNPE000172
Drug : DB00564 (Carbamazepine)
Interacting Gene/Enzyme : Flotillin-1
Gene Name : FLOT1
UniProt ID : O75955
Allele Name : HLA-B*1502
Genotype(s) : (G;G) / (C;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Patients with the CG or GG genotype (in Asian patients) were at a higher risk of Steven-Johnson Syndrome compared to those with the CC genotype (non-carriers of HLA-b*1502)
References :
- Locharernkul C, Loplumlert J, Limotai C, Korkij W, Desudchit T, Tongkobpetch S, Kangwanshiratada O, Hirankarn N, Suphapeetiporn K, Shotelersuk V: Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. Epilepsia. 2008 Dec;49(12):2087-91. doi: 10.1111/j.1528-1167.2008.01719.x. Epub 2008 Jul 14. [PubMed:18637831 ]
PMID: 19738058
Carbamazepine
Product: Bicyclomycin benzoate
Identifier : DBSNPE000173
Drug : DB00564 (Carbamazepine)
Interacting Gene/Enzyme : Mucin-21
Gene Name : MUC21
UniProt ID : Q5SSG8
Allele Name : HLA-B*1502
Genotype(s) : (G;G) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Patients with the AG or GG genotype (in Asian patients) were at a higher risk of Steven-Johnson Syndrome compared to those with the AA genotype
References :
- Locharernkul C, Loplumlert J, Limotai C, Korkij W, Desudchit T, Tongkobpetch S, Kangwanshiratada O, Hirankarn N, Suphapeetiporn K, Shotelersuk V: Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. Epilepsia. 2008 Dec;49(12):2087-91. doi: 10.1111/j.1528-1167.2008.01719.x. Epub 2008 Jul 14. [PubMed:18637831 ]
PMID: 19037093
Carbamazepine
Product: STO-609
Identifier : DBSNPE000180
Drug : DB00564 (Carbamazepine)
Interacting Gene/Enzyme : Flotillin-1
Gene Name : FLOT1
UniProt ID : O75955
Allele Name : HLA-B*1502
Genotype(s) : (G;G) / (C;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Patients with the CG or GG genotype (in Asian patients) were at a higher risk of Steven-Johnson Syndrome compared to those with the CC genotype (non-carriers of HLA-b*1502)
References :
- Chung WH, Hung SI, Hong HS, Hsih MS, Yang LC, Ho HC, Wu JY, Chen YT: Medical genetics: a marker for Stevens-Johnson syndrome. Nature. 2004 Apr 1;428(6982):486. [PubMed:15057820 ]
PMID: 16705092
Carbamazepine
Product: Osalmid
Identifier : DBSNPE000181
Drug : DB00564 (Carbamazepine)
Interacting Gene/Enzyme : Mucin-21
Gene Name : MUC21
UniProt ID : Q5SSG8
Allele Name : HLA-B*1502
Genotype(s) : (G;G) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Patients with the AG or GG genotype (in Asian patients) were at a higher risk of Steven-Johnson Syndrome compared to those with the AA genotype
References :
- Chung WH, Hung SI, Hong HS, Hsih MS, Yang LC, Ho HC, Wu JY, Chen YT: Medical genetics: a marker for Stevens-Johnson syndrome. Nature. 2004 Apr 1;428(6982):486. [PubMed:15057820 ]
PMID: 16674821
Carbamazepine
Product: SP-13786
Identifier : DBSNPE000232
Drug : DB00564 (Carbamazepine)
Interacting Gene/Enzyme : HLA class I histocompatibility antigen, B-15 alpha chain
Gene Name : HLA-B
UniProt ID : P30464
Allele Name : HLA-B*15:02
Genotype(s) : Not Available
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Increased risk of Stevens–Johnson syndrome and toxic epidermal necrolysis
References :
- Leckband SG, Kelsoe JR, Dunnenberger HM, George AL Jr, Tran E, Berger R, Muller DJ, Whirl-Carrillo M, Caudle KE, Pirmohamed M: Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosing. Clin Pharmacol Ther. 2013 Sep;94(3):324-8. doi: 10.1038/clpt.2013.103. Epub 2013 May 21. [PubMed:23695185 ]
PMID: 1348398
Carbamazepine
Product: Fluorescein-5-maleimide
Identifier : DBSNPE000261
Drug : DB00564 (Carbamazepine)
Interacting Gene/Enzyme : HLA class I histocompatibility antigen, A-3 alpha chain
Gene Name : HLA-A
UniProt ID : P04439
Allele Name : HLA-A*3101
Genotype(s) : (T;T) / (A;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Risk of hypersensitivity
References :
- McCormack M, Alfirevic A, Bourgeois S, Farrell JJ, Kasperaviciute D, Carrington M, Sills GJ, Marson T, Jia X, de Bakker PI, Chinthapalli K, Molokhia M, Johnson MR, OConnor GD, Chaila E, Alhusaini S, Shianna KV, Radtke RA, Heinzen EL, Walley N, Pandolfo M, Pichler W, Park BK, Depondt C, Sisodiya SM, Goldstein DB, Deloukas P, Delanty N, Cavalleri GL, Pirmohamed M: HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med. 2011 Mar 24;364(12):1134-43. doi: 10.1056/NEJMoa1013297. [PubMed:21428769 ]
PMID: 25425077