Bleomycin

Product: Iberin

Identifier : DBSNPE000067
Drug : DB00290 (Bleomycin)
Interacting Gene/Enzyme : Bleomycin hydrolase
Gene Name : BLMH
UniProt ID : Q13867
Defining Change(s) :

  • A Allele (rs10500565 )

Allele Name : Not Available
Genotype(s) : (A;A) / (A;G)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Improved response to bleomycin
References :

  1. de Haas EC, Zwart N, Meijer C, Nuver J, Boezen HM, Suurmeijer AJ, Hoeksdiva HJ, van der Steege G, Sleijfer DT, Gietema JA: Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer. J Clin Oncol. 2008 Apr 10;26(11):1817-23. doi: 10.1200/JCO.2007.14.1606. [PubMed:18398146 ]

PMID: 16627622

Bleomycin

Product: MLi-2

Identifier : DBSNPE000068
Drug : DB00290 (Bleomycin)
Interacting Gene/Enzyme : Bleomycin hydrolase
Gene Name : BLMH
UniProt ID : Q13867
Defining Change(s) :

  • G Allele (rs10500565 )

Allele Name : Not Available
Genotype(s) : (G;G)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Reduced response to bleomycin, higher prevalence of relapse
References :

  1. de Haas EC, Zwart N, Meijer C, Nuver J, Boezen HM, Suurmeijer AJ, Hoeksdiva HJ, van der Steege G, Sleijfer DT, Gietema JA: Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer. J Clin Oncol. 2008 Apr 10;26(11):1817-23. doi: 10.1200/JCO.2007.14.1606. [PubMed:18398146 ]

PMID: 17068343

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