Product Name :
BCR-ABL-IN-2
Description:
BCR-ABL-IN-2 is an inhibitor of BCR-ABL1 tyrosine kinase, with IC50s of 57 nM, 773 nm for ABL1native and ABL1T315I, respectively.
CAS:
897369-18-5
Molecular Weight:
502.39
Formula:
C24H25Cl2N5O3
Chemical Name:
(3S)-6-(3-tert-butyl-5-[(2,3-dichlorophenyl)carbamoyl]amino-1H-pyrazol-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
Smiles :
CC(C)(C)C1C=C(NC(=O)NC2=CC=CC(Cl)=C2Cl)N(N=1)C1=CC2C[C@H](NCC=2C=C1)C(O)=O
InChiKey:
CMUVVEBHULJOFP-SFHVURJKSA-N
InChi :
InChI=1S/C24H25Cl2N5O3/c1-24(2,3)19-11-20(29-23(34)28-17-6-4-5-16(25)21(17)26)31(30-19)15-8-7-13-12-27-18(22(32)33)10-14(13)9-15/h4-9,11,18,27H,10,12H2,1-3H3,(H,32,33)(H2,28,29,34)/t18-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BCR-ABL-IN-2 is an inhibitor of BCR-ABL1 tyrosine kinase, with IC50s of 57 nM, 773 nm for ABL1native and ABL1T315I, respectively.|Product information|CAS Number: 897369-18-5|Molecular Weight: 502.39|Formula: C24H25Cl2N5O3|Chemical Name: (3S)-6-(3-tert-butyl-5-[(2,3-dichlorophenyl)carbamoyl]amino-1H-pyrazol-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid|Smiles: CC(C)(C)C1C=C(NC(=O)NC2=CC=CC(Cl)=C2Cl)N(N=1)C1=CC2C[C@H](NCC=2C=C1)C(O)=O|InChiKey: CMUVVEBHULJOFP-SFHVURJKSA-N|InChi: InChI=1S/C24H25Cl2N5O3/c1-24(2,3)19-11-20(29-23(34)28-17-6-4-5-16(25)21(17)26)31(30-19)15-8-7-13-12-27-18(22(32)33)10-14(13)9-15/h4-9,11,18,27H,10,12H2,1-3H3,(H,32,33)(H2,28,29,34)/t18-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.Isatuximab Purity & Documentation |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.Trametinib Cancer |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BCR-ABL-IN-2 (Compound 1) contains a urea moiety to allow a hydrogen bond with the conserved K271-E286 salt bridge of ABL1, a t-butyl moiety to bind into the hydrophobic spine at the third pocket position, and a 2,3-dichlorophenyl ring to stabilize the DFG-phenylalanine F382 in the Type II-out conformation.PMID:32567018 BCR-ABL-IN-2 exhibits an IC50 of 57 nM for ABL1native and an IC50 of 773 nM for ABL1T315I. Despite ABL, BCR-ABL-IN-2 can also inhibit KDR, BRaf, p38 kinase with IC50s of 1.8 μM, 0.23 μM, 6.3 nM, 43 nM, respectively.|Products are for research use only. Not for human use.|