Product Name :
NVP-CGM097
Description:
CGM097 is an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival.
CAS:
1313363-54-0
Molecular Weight:
659.26
Formula:
C38H47ClN4O4
Chemical Name:
(1S)-1-(4-chlorophenyl)-6-methoxy-2-4-[methyl([4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl]methyl)amino]phenyl-7-(propan-2-yloxy)-1,2,3,4-tetrahydroisoquinolin-3-one
Smiles :
CC(C)OC1=CC2[C@H](C3=CC=C(Cl)C=C3)N(C3=CC=C(C=C3)N(C)CC3CCC(CC3)N3CCN(C)C(=O)C3)C(=O)CC=2C=C1OC
InChiKey:
CLRSLRWKONPSRQ-CPOWQTMSSA-N
InChi :
InChI=1S/C38H47ClN4O4/c1-25(2)47-35-22-33-28(20-34(35)46-5)21-36(44)43(38(33)27-8-10-29(39)11-9-27)32-16-14-30(15-17-32)41(4)23-26-6-12-31(13-7-26)42-19-18-40(3)37(45)24-42/h8-11,14-17,20,22,25-26,31,38H,6-7,12-13,18-19,21,23-24H2,1-5H3/t26?,31?,38-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CGM097 is an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity.Troglitazone Description Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53.Dofetilide Potassium Channel By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis.PMID:32628082 HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival.|Product information|CAS Number: 1313363-54-0|Molecular Weight: 659.26|Formula: C38H47ClN4O4|Synonym:|CGM097|CGM 097|CGM-097|NVP CGM097|Chemical Name: (1S)-1-(4-chlorophenyl)-6-methoxy-2-4-[methyl([4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl]methyl)amino]phenyl-7-(propan-2-yloxy)-1,2,3,4-tetrahydroisoquinolin-3-one|Smiles: CC(C)OC1=CC2[C@H](C3=CC=C(Cl)C=C3)N(C3=CC=C(C=C3)N(C)CC3CCC(CC3)N3CCN(C)C(=O)C3)C(=O)CC=2C=C1OC|InChiKey: CLRSLRWKONPSRQ-CPOWQTMSSA-N|InChi: InChI=1S/C38H47ClN4O4/c1-25(2)47-35-22-33-28(20-34(35)46-5)21-36(44)43(38(33)27-8-10-29(39)11-9-27)32-16-14-30(15-17-32)41(4)23-26-6-12-31(13-7-26)42-19-18-40(3)37(45)24-42/h8-11,14-17,20,22,25-26,31,38H,6-7,12-13,18-19,21,23-24H2,1-5H3/t26?,31?,38-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|