Product Name :
LEESGGGLVQPGGSMK
Description:
LEESGGGLVQPGGSMK, a proteolysis peptide, is a component of Infliximab. LEESGGGLVQPGGSMK can be used for quantitative analysis of Infliximab. Infliximab is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α.
CAS:
2096980-79-7
Molecular Weight:
1545.71
Formula:
C64H108N18O24S
Chemical Name:
(4S, 7S, 10S, 22S, 25S, 28S)-1-amino-4-((S)-2-((7S, 10S, 17S)-17-amino-17-carboxy-7-(hydroxymethyl)-10-(2-(methylthio)ethyl)-2, 5, 8, 11-tetraoxo-3, 6, 9, 12-tetraazaheptadecylcarbamoyl)pyrrolidine-1-carbonyl)-28-((S)-2-amino-4-methylpentanamido)-25-(2-carboxyethyl)-22-(hydroxymethyl)-10-isobutyl-7-isopropyl-1, 6, 9, 12, 15, 18, 21, 24, 27-nonaoxo-5, 8, 11, 14, 17, 20, 23, 26-octaazahentriacontan-31-oic acid
Smiles :
CSCC[C@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CC(C)C)C(C)C)C(=O)NCCCC[C@H](N)C(O)=O
InChiKey:
OJANTFHJDZIZAP-VCMHEWOTSA-N
InChi :
InChI=1S/C64H108N18O24S/c1-32(2)23-36(66)54(95)76-37(14-17-51(91)92)57(98)77-38(15-18-52(93)94)58(99)80-42(30-83)56(97)72-26-47(87)69-25-46(86)70-28-49(89)74-41(24-33(3)4)59(100)81-53(34(5)6)62(103)79-40(13-16-45(67)85)63(104)82-21-10-12-44(82)61(102)73-27-48(88)71-29-50(90)75-43(31-84)60(101)78-39(19-22-107-7)55(96)68-20-9-8-11-35(65)64(105)106/h32-44,53,83-84H,8-31,65-66H2,1-7H3,(H2,67,85)(H,68,96)(H,69,87)(H,70,86)(H,71,88)(H,72,97)(H,73,102)(H,74,89)(H,75,90)(H,76,95)(H,77,98)(H,78,101)(H,79,103)(H,80,99)(H,81,100)(H,91,92)(H,93,94)(H,105,106)/t35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,53-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Eliglustat Technical Information
Shelf Life:
≥12 months if stored properly.Octreotide References
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
LEESGGGLVQPGGSMK, a proteolysis peptide, is a component of Infliximab. LEESGGGLVQPGGSMK can be used for quantitative analysis of Infliximab. Infliximab is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α.|Product information|CAS Number: 2096980-79-7|Molecular Weight: 1545.71|Formula: C64H108N18O24S|Chemical Name: (4S, 7S, 10S, 22S, 25S, 28S)-1-amino-4-((S)-2-((7S, 10S, 17S)-17-amino-17-carboxy-7-(hydroxymethyl)-10-(2-(methylthio)ethyl)-2, 5, 8, 11-tetraoxo-3, 6, 9, 12-tetraazaheptadecylcarbamoyl)pyrrolidine-1-carbonyl)-28-((S)-2-amino-4-methylpentanamido)-25-(2-carboxyethyl)-22-(hydroxymethyl)-10-isobutyl-7-isopropyl-1, 6, 9, 12, 15, 18, 21, 24, 27-nonaoxo-5, 8, 11, 14, 17, 20, 23, 26-octaazahentriacontan-31-oic acid|Smiles: CSCC[C@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CC(C)C)C(C)C)C(=O)NCCCC[C@H](N)C(O)=O|InChiKey: OJANTFHJDZIZAP-VCMHEWOTSA-N|InChi: InChI=1S/C64H108N18O24S/c1-32(2)23-36(66)54(95)76-37(14-17-51(91)92)57(98)77-38(15-18-52(93)94)58(99)80-42(30-83)56(97)72-26-47(87)69-25-46(86)70-28-49(89)74-41(24-33(3)4)59(100)81-53(34(5)6)62(103)79-40(13-16-45(67)85)63(104)82-21-10-12-44(82)61(102)73-27-48(88)71-29-50(90)75-43(31-84)60(101)78-39(19-22-107-7)55(96)68-20-9-8-11-35(65)64(105)106/h32-44,53,83-84H,8-31,65-66H2,1-7H3,(H2,67,85)(H,68,96)(H,69,87)(H,70,86)(H,71,88)(H,72,97)(H,73,102)(H,74,89)(H,75,90)(H,76,95)(H,77,98)(H,78,101)(H,79,103)(H,80,99)(H,81,100)(H,91,92)(H,93,94)(H,105,106)/t35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,53-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:33229916 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The anti-TNF antibodies blocking the action of TNF alpha revolutionized therapy of TNF-related diseases such as Inflammatory Bowel Disease, lupus, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis and rheumatoid arthritis. By neutralizing TNF activity, anti-TNF antibodies promote mucosal healing and induce long-term remissions in vivo. The main anti-TNF antibodies that are currently authorized encompass Infliximab, Etanercept, Adalimumab, Certolizumab and Golimumab.|References:|Dorothée LEBERT, et al. A method for quantifying therapeutic antibodies. EP3371592A1.Products are for research use only. Not for human use.|