Product Name :
Bax activator-1
Description:
Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis.
CAS:
1638526-94-9
Molecular Weight:
488.62
Formula:
C29H36N4O3
Chemical Name:
(3R)-1-5-[(3, 4-dimethylphenyl)methyl]-1-[(3-methoxyphenyl)methyl]-1H, 4H, 5H, 6H, 7H-pyrazolo[4, 3-c]pyridine-3-carbonylpiperidin-3-ol
Smiles :
CC1=CC(CN2CC3C(=NN(CC4C=C(C=CC=4)OC)C=3CC2)C(=O)N2C[C@H](O)CCC2)=CC=C1C
InChiKey:
OLNVSYZSZXRLCF-XMMPIXPASA-N
InChi :
InChI=1S/C29H36N4O3/c1-20-9-10-23(14-21(20)2)16-31-13-11-27-26(19-31)28(29(35)32-12-5-7-24(34)18-32)30-33(27)17-22-6-4-8-25(15-22)36-3/h4,6,8-10,14-15,24,34H,5,7,11-13,16-19H2,1-3H3/t24-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis.|Product information|CAS Number: 1638526-94-9|Molecular Weight: 488.62|Formula: C29H36N4O3|Chemical Name: (3R)-1-5-[(3, 4-dimethylphenyl)methyl]-1-[(3-methoxyphenyl)methyl]-1H, 4H, 5H, 6H, 7H-pyrazolo[4, 3-c]pyridine-3-carbonylpiperidin-3-ol|Smiles: CC1=CC(CN2CC3C(=NN(CC4C=C(C=CC=4)OC)C=3CC2)C(=O)N2C[C@H](O)CCC2)=CC=C1C|InChiKey: OLNVSYZSZXRLCF-XMMPIXPASA-N|InChi: InChI=1S/C29H36N4O3/c1-20-9-10-23(14-21(20)2)16-31-13-11-27-26(19-31)28(29(35)32-12-5-7-24(34)18-32)30-33(27)17-22-6-4-8-25(15-22)36-3/h4,6,8-10,14-15,24,34H,5,7,11-13,16-19H2,1-3H3/t24-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Cediranib Protocol |Shelf Life: ≥12 months if stored properly.Nelfinavir Epigenetic Reader Domain |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32551747 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Bax activator-1 (20-80 μM; 48 hours) induces Bax-dependent tumor cell apoptosis in a dose-dependent fashion.|In Vivo:|Bax activator-1 (40 mg/kg; given i.p., each day for 13 days) inhibits lung tumor growth in C57BL/6 female mice.|References:|Zhao G, et al. Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis. Mol Cell Biol. 2014 Apr;34(7):1198-207.Products are for research use only. Not for human use.|