Product Name :
GR 125743
Description:
GR 125743 is a selective 5-HT1B/1D receptor antagonist, with pKis of 8.85 and 8.31 for wild-type h5-HT1B and wild-type h5-HT1D, respectively. GR 125743 is used for the research of Parkinson’s disease and cardiovascular diseases.
CAS:
148547-33-5
Molecular Weight:
416.52
Formula:
C25H28N4O2
Chemical Name:
N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-4-(pyridin-4-yl)benzamide
Smiles :
CN1CCN(CC1)C1=CC(=CC=C1OC)NC(=O)C1=CC(C)=C(C=C1)C1C=CN=CC=1
InChiKey:
GNOXPYACARZYMW-UHFFFAOYSA-N
InChi :
InChI=1S/C25H28N4O2/c1-18-16-20(4-6-22(18)19-8-10-26-11-9-19)25(30)27-21-5-7-24(31-3)23(17-21)29-14-12-28(2)13-15-29/h4-11,16-17H,12-15H2,1-3H3,(H,27,30)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{3,3′-Diindolylmethane} MedChemExpress|{3,3′-Diindolylmethane} Autophagy|{3,3′-Diindolylmethane} Protocol|{3,3′-Diindolylmethane} Purity|{3,3′-Diindolylmethane} supplier|{3,3′-Diindolylmethane} Cancer}
Shelf Life:
≥12 months if stored properly.{{Galiximab} medchemexpress|{Galiximab} Immunology/Inflammation|{Galiximab} Purity & Documentation|{Galiximab} Data Sheet|{Galiximab} custom synthesis|{Galiximab} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
GR 125743 is a selective 5-HT1B/1D receptor antagonist, with pKis of 8.85 and 8.31 for wild-type h5-HT1B and wild-type h5-HT1D, respectively. GR 125743 is used for the research of Parkinson’s disease and cardiovascular diseases.|Product information|CAS Number: 148547-33-5|Molecular Weight: 416.52|Formula: C25H28N4O2|Chemical Name: N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-4-(pyridin-4-yl)benzamide|Smiles: CN1CCN(CC1)C1=CC(=CC=C1OC)NC(=O)C1=CC(C)=C(C=C1)C1C=CN=CC=1|InChiKey: GNOXPYACARZYMW-UHFFFAOYSA-N|InChi: InChI=1S/C25H28N4O2/c1-18-16-20(4-6-22(18)19-8-10-26-11-9-19)25(30)27-21-5-7-24(31-3)23(17-21)29-14-12-28(2)13-15-29/h4-11,16-17H,12-15H2,1-3H3,(H,27,30)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (240.PMID:32037501 08 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|GR 125743 has a Kd of 0.61 nM for h5-HT1B.|In Vivo:|GR 125743 (0.3 mg/kg; i.p.) produces significant decreases in extracellular 5-HT in the frontal cortex of the conscious guinea pig.|Products are for research use only. Not for human use.|