Product Name :
CHPG
Description:
CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.
CAS:
170846-74-9
Molecular Weight:
201.61
Formula:
C8H8ClNO3
Chemical Name:
2-amino-2-(2-chloro-5-hydroxyphenyl)acetic acid
Smiles :
NC(C1=CC(O)=CC=C1Cl)C(O)=O
InChiKey:
UNIDAFCQFPGYJJ-UHFFFAOYSA-N
InChi :
InChI=1S/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Mefenamic acid} site|{Mefenamic acid} Immunology/Inflammation|{Mefenamic acid} Biological Activity|{Mefenamic acid} References|{Mefenamic acid} supplier|{Mefenamic acid} Epigenetic Reader Domain}
Additional information:
CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells.{{Interferon alfa} MedChemExpress|{Interferon alfa} IFNAR|{Interferon alfa} Technical Information|{Interferon alfa} In stock|{Interferon alfa} supplier|{Interferon alfa} Autophagy} CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.PMID:31891275 |Product information|CAS Number: 170846-74-9|Molecular Weight: 201.61|Formula: C8H8ClNO3|Chemical Name: 2-amino-2-(2-chloro-5-hydroxyphenyl)acetic acid|Smiles: NC(C1=CC(O)=CC=C1Cl)C(O)=O|InChiKey: UNIDAFCQFPGYJJ-UHFFFAOYSA-N|InChi: InChI=1S/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CHPG (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO2 derivatives treatment. CHPG (0.5 mM; 30 mins ) protects BV2 cells against SO2-induced apoptosis. CHPG (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels.|In Vivo:|CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.|References:|Qiu JL, et al. The selective mGluR5 agonist CHPG attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Neurochem Int. 2015 Jun-Jul;85-86:46-52.Products are for research use only. Not for human use.|