Product Name :
Implitapide
Description:
Implitapide (AEGR 427) is a microsomal triglyceride transfer protein (MTP) inhibitor.
CAS:
177469-96-4
Molecular Weight:
531.69
Formula:
C35H37N3O2
Chemical Name:
2-cyclopentyl-2-[4-({2,4-dimethyl-9H-pyrido[2,3-b]indol-9-yl}methyl)phenyl]-N-(2-hydroxy-1-phenylethyl)acetamide
Smiles :
CC1C=C(C)N=C2C=1C1=CC=CC=C1N2CC1C=CC(=CC=1)C(C1CCCC1)C(=O)NC(CO)C1C=CC=CC=1
InChiKey:
KIMRCJZMVARVSU-UHFFFAOYSA-N
InChi :
InChI=1S/C35H37N3O2/c1-23-20-24(2)36-34-32(23)29-14-8-9-15-31(29)38(34)21-25-16-18-28(19-17-25)33(27-12-6-7-13-27)35(40)37-30(22-39)26-10-4-3-5-11-26/h3-5,8-11,14-20,27,30,33,39H,6-7,12-13,21-22H2,1-2H3,(H,37,40)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Implitapide (AEGR 427) is a microsomal triglyceride transfer protein (MTP) inhibitor.|Product information|CAS Number: 177469-96-4|Molecular Weight: 531.69|Formula: C35H37N3O2|Chemical Name: 2-cyclopentyl-2-[4-({2,4-dimethyl-9H-pyrido[2,3-b]indol-9-yl}methyl)phenyl]-N-(2-hydroxy-1-phenylethyl)acetamide|Smiles: CC1C=C(C)N=C2C=1C1=CC=CC=C1N2CC1C=CC(=CC=1)C(C1CCCC1)C(=O)NC(CO)C1C=CC=CC=1|InChiKey: KIMRCJZMVARVSU-UHFFFAOYSA-N|InChi: InChI=1S/C35H37N3O2/c1-23-20-24(2)36-34-32(23)29-14-8-9-15-31(29)38(34)21-25-16-18-28(19-17-25)33(27-12-6-7-13-27)35(40)37-30(22-39)26-10-4-3-5-11-26/h3-5,8-11,14-20,27,30,33,39H,6-7,12-13,21-22H2,1-2H3,(H,37,40)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Vaborbactam} medchemexpress|{Vaborbactam} Bacterial|{Vaborbactam} Protocol|{Vaborbactam} Data Sheet|{Vaborbactam} supplier|{Vaborbactam} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Enzalutamide} web|{Enzalutamide} Vitamin D Related/Nuclear Receptor|{Enzalutamide} Biological Activity|{Enzalutamide} Purity|{Enzalutamide} supplier|{Enzalutamide} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23847952 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Implitapide suppresses MTP activity using a recombinant human form complexed with protein disulphide isomerase (IC50=10 nM) and inhibit secretion of apoB-containing very low-density lipoprotein (VLDL)-like lipoproteins from a human hepatoma cell (HepG2) with an IC50 value of 1.1 nM.|In Vivo:|Implitapide (3.2 mg/kg/d) significantly reduces the plasma lipid levels to nearly or below the chow diet (CD) level at 4 and 8 weeks of treatment (pProducts are for research use only. Not for human use.|