Product Name :
HZ52
Description:
2-(4-(biphenyl-4-ylamino)-6-chloropyrimidin-2- ylthio)octanoic acid (HZ52) is an inhibitor for 5-Lipoxygenase (5-LO) . 5-Lipoxygenase (5-LO), the key enzyme involved in the biosynthesis of pro-inflammatory leukotrienes (LTs), is a potential target for pharmacological intervention with inflammation and allergic disorders . In vitro: In cell-free assays using partially purified recombinant 5-LO enzyme, HZ52 inhibited 5-LO with an IC50 of 1.5 μM. In PMNL homogenates, HZ52 inhibited 5-LO with an IC50 of 9 μM . HZ52 (10 or 30 μM) promoted 5-LO translocation to the nuclear membrane in PMNL . The cell-based and cell-free assays revealed that inhibition of 5-LO by HZ52 did not depend on radical scavenging properties and was reversible . In vivo: In rats with carrageenan-induced pleurisy and in mice bearing platelet-activating factor (PAF)-induced lethal shock, HZ52 (1.5 mg/kg, i.p) prevented carrageenan-induced pleurisy accompanied by reducing LTB4 levels. HZ52 protected mice (10 mg/kg, i.p) against PAF-induced shock. .
CAS:
1077626-51-7
Molecular Weight:
456.00
Formula:
C24H26ClN3O2S
Chemical Name:
2-{[4-({[1,1′-biphenyl]-4-yl}amino)-6-chloropyrimidin-2-yl]sulfanyl}octanoic acid
Smiles :
CCCCCCC(SC1N=C(C=C(Cl)N=1)NC1C=CC(=CC=1)C1C=CC=CC=1)C(O)=O
InChiKey:
MLNIGXYHGQLWLD-UHFFFAOYSA-N
InChi :
InChI=1S/C24H26ClN3O2S/c1-2-3-4-8-11-20(23(29)30)31-24-27-21(25)16-22(28-24)26-19-14-12-18(13-15-19)17-9-6-5-7-10-17/h5-7,9-10,12-16,20H,2-4,8,11H2,1H3,(H,29,30)(H,26,27,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Efavirenz} medchemexpress|{Efavirenz} Autophagy|{Efavirenz} Technical Information|{Efavirenz} In Vivo|{Efavirenz} custom synthesis|{Efavirenz} Epigenetics}
Shelf Life:
≥12 months if stored properly.{{Esomeprazole} site|{Esomeprazole} Bacterial|{Esomeprazole} Protocol|{Esomeprazole} Formula|{Esomeprazole} manufacturer|{Esomeprazole} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23613863
Additional information:
2-(4-(biphenyl-4-ylamino)-6-chloropyrimidin-2- ylthio)octanoic acid (HZ52) is an inhibitor for 5-Lipoxygenase (5-LO) . 5-Lipoxygenase (5-LO), the key enzyme involved in the biosynthesis of pro-inflammatory leukotrienes (LTs), is a potential target for pharmacological intervention with inflammation and allergic disorders . In vitro: In cell-free assays using partially purified recombinant 5-LO enzyme, HZ52 inhibited 5-LO with an IC50 of 1.5 μM. In PMNL homogenates, HZ52 inhibited 5-LO with an IC50 of 9 μM . HZ52 (10 or 30 μM) promoted 5-LO translocation to the nuclear membrane in PMNL . The cell-based and cell-free assays revealed that inhibition of 5-LO by HZ52 did not depend on radical scavenging properties and was reversible . In vivo: In rats with carrageenan-induced pleurisy and in mice bearing platelet-activating factor (PAF)-induced lethal shock, HZ52 (1.5 mg/kg, i.p) prevented carrageenan-induced pleurisy accompanied by reducing LTB4 levels. HZ52 protected mice (10 mg/kg, i.p) against PAF-induced shock. .|Product information|CAS Number: 1077626-51-7|Molecular Weight: 456.00|Formula: C24H26ClN3O2S|Chemical Name: 2-{[4-({[1,1′-biphenyl]-4-yl}amino)-6-chloropyrimidin-2-yl]sulfanyl}octanoic acid|Smiles: CCCCCCC(SC1N=C(C=C(Cl)N=1)NC1C=CC(=CC=1)C1C=CC=CC=1)C(O)=O|InChiKey: MLNIGXYHGQLWLD-UHFFFAOYSA-N|InChi: InChI=1S/C24H26ClN3O2S/c1-2-3-4-8-11-20(23(29)30)31-24-27-21(25)16-22(28-24)26-19-14-12-18(13-15-19)17-9-6-5-7-10-17/h5-7,9-10,12-16,20H,2-4,8,11H2,1H3,(H,29,30)(H,26,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|