Product Name :
Mestranol
Description:
Mestranol is an Estrogen. The mechanism of action of mestranol is as an Estrogen Receptor Agonist. It is used as the estrogen component of many combination oral contraceptives.
CAS:
72-33-3
Molecular Weight:
310.43
Formula:
C21H26O2
Chemical Name:
17-ethynyl-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol
Smiles :
CC12CCC3C(CCC4=CC(=CC=C43)OC)C1CCC2(O)C#C
InChiKey:
IMSSROKUHAOUJS-UHFFFAOYSA-N
InChi :
InChI=1S/C21H26O2/c1-4-21(22)12-10-19-18-7-5-14-13-15(23-3)6-8-16(14)17(18)9-11-20(19,21)2/h1,6,8,13,17-19,22H,5,7,9-12H2,2-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Abciximab} MedChemExpress|{Abciximab} Integrin|{Abciximab} Biological Activity|{Abciximab} Purity|{Abciximab} manufacturer|{Abciximab} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Mestranol is an Estrogen. The mechanism of action of mestranol is as an Estrogen Receptor Agonist. It is used as the estrogen component of many combination oral contraceptives.|Product information|CAS Number: 72-33-3|Molecular Weight: 310.43|Formula: C21H26O2|Synonym:|Devocin|Norquen|Ovastol|Ethynylestradiol 3-methyl ether|Ethinyl Estradiol 3 Methyl Ether|Ethinyl Estradiol 3-Methyl Ether|Chemical Name: 17-ethynyl-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol|Smiles: CC12CCC3C(CCC4=CC(=CC=C43)OC)C1CCC2(O)C#C|InChiKey: IMSSROKUHAOUJS-UHFFFAOYSA-N|InChi: InChI=1S/C21H26O2/c1-4-21(22)12-10-19-18-7-5-14-13-15(23-3)6-8-16(14)17(18)9-11-20(19,21)2/h1,6,8,13,17-19,22H,5,7,9-12H2,2-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 15 mg/mL(48.32 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Mestranol is extensively metabolized to hydroxylated products whose bio- logical activity is less well characterized.|In Vivo:|Mestranol (0.2 mg/kg) results in an increased percentage of liver occupied by AHF expressing glutathione S-transferase (PGST) in rats. Mestranol administration increases the focal hepatocyte labeling index compared with the control with a trend at the lower dose and a significant difference at the higher dose.{{Isatuximab (anti-CD38)} site|{Isatuximab (anti-CD38)} CD38|{Isatuximab (anti-CD38)} NF-κB|{Isatuximab (anti-CD38)} Protocol|{Isatuximab (anti-CD38)} References|{Isatuximab (anti-CD38)} manufacturer} Mestranol (0.PMID:23724934 02 mg/kg and 0.2 mg/kg diet) results in a decrease in the non-focal labeling index compared with that observed for the corresponding concentration of Mestranol alone. Mestranol significantly increases the non-focal hepatic labeling index in uninitiated rats compared with that observed in rats administered the basal diet only. Mestranol (50 mg/100 g b.wt.) has a significant reduction in the apparent number of alpha-2-adrenoceptors in the frontal cortex and nucleus tractus solitarius (NTS) of rat, while apparent numbers of both alpha-1 and alpha-2-adrenoceptors are depressed in the locus coeruleus.|References:|Shackelford DP Jr, et al. Brain Res Bull, 1988, 21(2), 329-333.Dragan YP, et al. Carcinogenesis, 1996, 17(9), 2043-2052.Products are for research use only. Not for human use.|