Product Name :
KR-33493
Description:
KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1).
CAS:
1021497-97-1
Molecular Weight:
460.34
Formula:
C20H18BrN3O3S
Chemical Name:
4-{2-[(4-bromophenyl)sulfanyl]acetamido}-1-(2-phenylethyl)-1H-pyrazole-3-carboxylic acid
Smiles :
OC(=O)C1=NN(CCC2C=CC=CC=2)C=C1NC(=O)CSC1C=CC(Br)=CC=1
InChiKey:
ZRLJEHIUGYTTSZ-UHFFFAOYSA-N
InChi :
InChI=1S/C20H18BrN3O3S/c21-15-6-8-16(9-7-15)28-13-18(25)22-17-12-24(23-19(17)20(26)27)11-10-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2,(H,22,25)(H,26,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1).|Product information|CAS Number: 1021497-97-1|Molecular Weight: 460.34|Formula: C20H18BrN3O3S|Chemical Name: 4-{2-[(4-bromophenyl)sulfanyl]acetamido}-1-(2-phenylethyl)-1H-pyrazole-3-carboxylic acid|Smiles: OC(=O)C1=NN(CCC2C=CC=CC=2)C=C1NC(=O)CSC1C=CC(Br)=CC=1|InChiKey: ZRLJEHIUGYTTSZ-UHFFFAOYSA-N|InChi: InChI=1S/C20H18BrN3O3S/c21-15-6-8-16(9-7-15)28-13-18(25)22-17-12-24(23-19(17)20(26)27)11-10-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2,(H,22,25)(H,26,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 31 mg/mL (67.{{Dexrazoxane} web|{Dexrazoxane} Purity & Documentation|{Dexrazoxane} Data Sheet|{Dexrazoxane} supplier|{Dexrazoxane} Autophagy} 34 mM).{{Irinotecan} medchemexpress|{Irinotecan} Autophagy|{Irinotecan} Protocol|{Irinotecan} References|{Irinotecan} supplier|{Irinotecan} Epigenetics} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:25040798 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Body weight changes of both sexes are not related to KR-33493 in all doses. In rats administrated KR-33493 for 4 weeks, no test article-related changes in any treated groups of either sex are found in hematology, serum biochemistry, and urinalysis. In dogs administrated KR-33493 for 2 weeks, red blood cell count (RBC) value in males is significantly higher at the 1000 mg/kg/day dose than that of the control group (i.e., 6.96±0.323 vs. 6.12±0.418). However, the change of RBC is recovered after the end of the administration period. The dose-normalized AUClast is not significantly different between the groups, suggesting that KR-33493 is governed by linear kinetics.|Products are for research use only. Not for human use.|