Product Name :
Apoptosis Inhibitor
Description:
M50054, 2,2′-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. In human Fas-expressing WC8 cells, M50054 inhibited apoptosis by soluble human Fas ligand in vitro cell death assay. M50054 inhibited the apoptotic U937 cell death which is a human monocytic leukemic cell line, induced by anticancer agents such as etoposide. M50054 inhibited apoptotic characters such as DNA phosphatidylserine and fragmentation exposure in these cells. These anti-apoptotic effects were dependent on inhibition of caspase-3 activation. Additionally, M50054 significantly inhibited anti-Fas-antibody-induced elevation of plasma aspartate aminotransferase and alanine aminotransferase. Alopecia (hair loss) symptoms were also significantly improved with topical treatment with M50054. M50054 inhibits apoptosis induced by a variety of stimuli via inhibition of caspase-3 activation, and may thus be effective for hepatitis and chemotherapy-induced alopecia.
CAS:
54135-60-3
Molecular Weight:
236.{{Venetoclax} site|{Venetoclax} Autophagy|{Venetoclax} Biological Activity|{Venetoclax} References|{Venetoclax} custom synthesis|{Venetoclax} Epigenetic Reader Domain} 26
Formula:
C13H16O4
Chemical Name:
2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione
Smiles :
O=C1CCCC(=O)C1CC1C(=O)CCCC1=O
InChiKey:
ILUMEPMGPCKGHH-UHFFFAOYSA-N
InChi :
InChI=1S/C13H16O4/c14-10-3-1-4-11(15)8(10)7-9-12(16)5-2-6-13(9)17/h8-9H,1-7H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Avatrombopag} site|{Avatrombopag} Thrombopoietin Receptor|{Avatrombopag} Protocol|{Avatrombopag} Data Sheet|{Avatrombopag} manufacturer|{Avatrombopag} Epigenetics}
Shelf Life:
≥12 months if stored properly.PMID:23710097
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
M50054, 2,2′-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. In human Fas-expressing WC8 cells, M50054 inhibited apoptosis by soluble human Fas ligand in vitro cell death assay. M50054 inhibited the apoptotic U937 cell death which is a human monocytic leukemic cell line, induced by anticancer agents such as etoposide. M50054 inhibited apoptotic characters such as DNA phosphatidylserine and fragmentation exposure in these cells. These anti-apoptotic effects were dependent on inhibition of caspase-3 activation. Additionally, M50054 significantly inhibited anti-Fas-antibody-induced elevation of plasma aspartate aminotransferase and alanine aminotransferase. Alopecia (hair loss) symptoms were also significantly improved with topical treatment with M50054. M50054 inhibits apoptosis induced by a variety of stimuli via inhibition of caspase-3 activation, and may thus be effective for hepatitis and chemotherapy-induced alopecia.|Product information|CAS Number: 54135-60-3|Molecular Weight: 236.26|Formula: C13H16O4|Chemical Name: 2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione|Smiles: O=C1CCCC(=O)C1CC1C(=O)CCCC1=O|InChiKey: ILUMEPMGPCKGHH-UHFFFAOYSA-N|InChi: InChI=1S/C13H16O4/c14-10-3-1-4-11(15)8(10)7-9-12(16)5-2-6-13(9)17/h8-9H,1-7H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|