Ucted making use of Stata 10.1 (StataCorp, College Station, TX, USA).ResultsCharacteristics of individuals
Ucted employing Stata ten.1 (StataCorp, College Station, TX, USA).ResultsCharacteristics of patients with undiagnosed COPDThe entire PAC-COPD cohort incorporated 342 patients (93 men) having a mean (SD) age of 67 (9) years and aTable 1 Baseline traits of 342 COPD patients recruited at their initially hospitalisation for a COPD exacerbationAll COPD sufferers Undiagnosed COPD Diagnosed COPD p-value n = 342* n = 117 (34 ) n = 225 (66 ) Age (years), m (SD) Males, n ( ) Married, n ( ) Much less than main education, n ( ) Low socioeconomic status (IV-V), n ( ) Present workers, n ( ) Smoking status: existing, n ( ) Pack-years, m (SD) Physical activity (hours/week), m (SD) 2 comorbidities (Charlson index), n ( ) Severity of COPD (ERS/ATS), n ( ) Mild (FEV1 80 ) Moderate (FEV1 50 , 80 ) Serious (FEV1 30 , 50 ) Quite serious (FEV1 30 ) FEV1 post-bronchodilator ( pred), m (SD) DLCO ( pred.), m (SD) RV/TLC ( ), m (SD) PaO2 (mmHg), m (SD) PaCO2 (mmHg), m (SD) 6MWD (m), median (P25-P75) Dyspnoea score (mMRC, score 0), m (SD) BMI (Kg/m2), m (SD) FFMI (Kg/m ), m (SD) SGRQ total score (0 no health impairment to one hundred maximum impairment), m (SD) SGRQ symptoms score, m (SD)67 (9) 318 (93) 274 (80) 142 (42) 259 (82) 61 (18) 150 (44) 69 (40) 33.five (23.eight) 172 (50)66 (9) 107 (92) 90 (77) 46 (39) 90 (81) 30 (26) 69 (59) 67 (38) 39.five (23.four) 47 (40)68 (eight) 211(94) 184 (82) 96 (43) 169 (82) 31 (14) 81 (36) 70 (41) 30.4 (23.five) 125 (56)0.03 0.43 0.29 0.55 0.83 0.01 0.01 0.55 0.01 0.19 (5) 164 (48) 132 (39) 27 (eight) 52 (16) 65 (21) 56 (10) 74 (11) 41.eight (5.3) 437 (39000) 2.40 (1.06) 28.two (4.7) 19.7 (three.1) 37 (18) 48 (18)14 (12) 65 (56) 33 (28) five (four) 59 (16) 67 (21) 52 (ten) 75 (ten) 42.two (5.two) 440 (39602) two.06 (1.09) 28.eight (four.7) 19.9 (3.0) 29 (16) 45 (16)5 (two) 99 (44) 99 (44) 22 (ten) 49 (15) 64 (21) 58 (9) 74 (11) 41.six (five.4) 437 (37398) 2.59 (0.99) 27.9 (four.six) 19.5 (three.1) 40 (18) 50 (18)0.0.01 0.23 0.01 0.28 0.37 0.25 0.01 0.08 0.21 0.01 0.ERS/ATS: European Respiratory Society/American Thoracic Society; FEV1: forced expiratory volume in 1 second; FEV1/FVC: forced expiratory volume in 1 second/ forced essential capacity; RV/TLC: Residual Volume/Total Lung Capacity; DLCO: diffusing capacity for carbon monoxide; PaO2: arterial oxygen tension; PaCO2: arterial carbon dioxide tension; 6MWD: six-minute walking distance; mMRC: modified Healthcare Study Council; BMI: body mass index; FFMI: fat-free mass index; SGRQ: St. George’s Respiratory Questionnaire. *Some variables had missing values: 25 in socioeconomic status, a single in physical activity, 4 in dyspnoea, 27 in RV/TLC, 46 in DLCO, 11 in PaO2, 10 in PaCO2, 33 in 6MWD, 13 in FFMI, and four in SGRQ score. CXCR3 supplier Comparison amongst undiagnosed and previously diagnosed COPD.Balcells et al. BMC Pulmonary Medicine 2015, 15:4 biomedcentral.com/1471-2466/15/Page five ofmean (SD) post-bronchodilator FEV1 of 52 (16 ) predicted throughout clinical stability (Table 1). A total of 117 sufferers (34 ) fulfilled the criteria of “undiagnosed COPD”. Table 1 shows the comparisons of sociodemographic and clinical traits for these two groups. Undiagnosed patients have been younger and much more physically active, had fewer symptoms and far better LTC4 manufacturer overall health status, and had milder airflow limitation and fewer comorbidities; moreover a greater proportion of those sufferers reported that they at present smoked (Table 1). A total of 33 (28 ) individuals with severe COPD and 5 (four ) sufferers with extremely extreme COPD reported that they had never been diagnosed as obtaining a respiratory disease prior.