Ch ard et al. BMC Systems Biology :Web page ofAdditional file R
Ch ard et al. BMC Systems Biology :Web page ofAdditional file R code for the simulation and validation if iTCadip. (ZIP kb) Extra file Figure_S. Graph from the effect of each gene’s deletion on both biomass and lipid droplet production when compared with the wild form network when glucose and TAG uptake are restricted. Table_S.docx. PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/19116884 Biomass and lipid droplet constituent with stoichiometry at the same time as development media definition. Table_S.xlsx. List of metabolic tasks used to insure right network behavior under numerous circumstances. Table_S.xlsx. List of fluxes for imports and exports in the network at each and every time point when optimising for lipid droplet production with restrictions to the SGC707 biological activity values of TAG extraction, glucose uptake and NEFA release for the experimental values from obese and lean subjects. Table_S.xlsx. List of fluxes for imports and exports within the network at every time point when optimising for acetylCoA production with restrictions to the values of TAG extraction, glucose uptake and NEFA release towards the experimental values from obese and lean subjects. Table_S.xlsx. Effect of gene deletion in mouse models for the genes predicted to have an effect on adipocyte hypertrophy. Table_S.docx. Quantity of genes getting an elevated effect on lipid droplet and biomass production in either with the adipose tissues in comparison to the other. Table_S.xlsx. List of genes identified as prospective targets when restricting the flux of reactions applying gene fold differences involving subcutaneous and visceral adipose tissues. iTCadip.xml and iTCadipRaven.xml files containing the iTCadip network in SDML and raven formats as described above. (ZIP kb)Publisher’s NoteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Author details Division of Pharmacology and Physiology, Faculty of Medicine, Universitde Montr l, Montreal, QC, Canada. Department of Biochemistry, Faculty of Medicine and Wellness Sciences, Universitde Sherbrooke, Sherbrooke, Canada. Institute of Nutrition and Functional Foods, UniversitLaval, Quebec City, Canada. School of Nutrition, UniversitLaval, Quebec City, Canada. Division of Endocrinology, Department of Medicine, Centre de recherche du CHUS, Universitde Sherbrooke, Sherbrooke, Canada. Centre de Recherche de l’Institut universitaire de cardiologie et de pneumologie de Qu ec, Quebec City, QC, Canada. ReceivedNovember AcceptedJune RN is a member in the Fonds de Recherche du Qu ec en Nature et Technologie (FRQNT) funded PROTEO network (the Qu ec network for study on protein function, structure and engineering) plus the FRQS funded GRASP (Groupe de Recherche Axsur la Structure des Prot nes) network. Funding TC was partially funded by a master’s scholarship from the Fonds de Recherche du Qu ec en Sant(FRQS) and also a CREMUS graduate fellowship in the Faculty of Medecine, Universitde Sherbrooke and at the moment holds a doctorate scholarship in the FRQS. MCV is Tier Canada Research Chair in Genomics Applied to Nutrition and Well being. AC could be the GSK Chair in Diabetes of Universitde Sherbrooke.
AT receives investigation funding from Johnson Johnson Health-related Companies for studies unrelated to this manuscript. RN would be the recipient of a FRQS Junior salary fellowship. This project was funded by the Organic Sciences and Engineering Study Council of Canada (NSERC) Discovery Grant RGPIN. None with the funding agencies had any role inside the design and style in the study and collection, evaluation, and interpretation of information a.