PI3KInhibitorpi3kinhibitor

Voriconazole

By

Voriconazole

Product: Emixustat

Identifier : DBSNPE000244
Drug : DB00582 (Voriconazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • C > T (rs12248560 )

Allele Name : CYPC19*17
Genotype(s) : (T;T) / (C;T)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Higher dose requirement
References :

  1. Moriyama B, Obeng AO, Barbarino J, Penzak SR, Henning SA, Scott SA, Agundez JA, Wingard JR, McLeod HL, Klein TE, Cross S, Caudle KE, Walsh TJ: Clinical Pharmacogenetics Implementation Consortium (CPIC(R)) Guideline for CYP2C19 and Voriconazole Therapy. Clin Pharmacol Ther. 2016 Dec 16. doi: 10.1002/cpt.583. [PubMed:27981572 ]

PMID: 24517977

Voriconazole

By

Voriconazole

Product: Afatinib (dimaleate)

Identifier : DBSNPE005154
Drug : DB00582 (Voriconazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 681G>A (rs4244285 )

Allele Name : CYP2C19*2A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders
References :

  1. Moriyama B, Obeng AO, Barbarino J, Penzak SR, Henning SA, Scott SA, Agundez JA, Wingard JR, McLeod HL, Klein TE, Cross S, Caudle KE, Walsh TJ: Clinical Pharmacogenetics Implementation Consortium (CPIC(R)) Guideline for CYP2C19 and Voriconazole Therapy. Clin Pharmacol Ther. 2016 Dec 16. doi: 10.1002/cpt.583. [PubMed:27981572 ]

PMID: 18777108

Voriconazole

By

Voriconazole

Product: DOXO-EMCH

Identifier : DBSNPE005155
Drug : DB00582 (Voriconazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 681G>A (rs4244285 )

Allele Name : CYP2C19*2B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders
References :

  1. Moriyama B, Obeng AO, Barbarino J, Penzak SR, Henning SA, Scott SA, Agundez JA, Wingard JR, McLeod HL, Klein TE, Cross S, Caudle KE, Walsh TJ: Clinical Pharmacogenetics Implementation Consortium (CPIC(R)) Guideline for CYP2C19 and Voriconazole Therapy. Clin Pharmacol Ther. 2016 Dec 16. doi: 10.1002/cpt.583. [PubMed:27981572 ]

PMID: 14679185

Voriconazole

By

Voriconazole

Product: Palbociclib (hydrochloride)

Identifier : DBSNPE005156
Drug : DB00582 (Voriconazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 636G>A (rs4986893 )

Allele Name : CYP2C19*3
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders
References :

  1. Moriyama B, Obeng AO, Barbarino J, Penzak SR, Henning SA, Scott SA, Agundez JA, Wingard JR, McLeod HL, Klein TE, Cross S, Caudle KE, Walsh TJ: Clinical Pharmacogenetics Implementation Consortium (CPIC(R)) Guideline for CYP2C19 and Voriconazole Therapy. Clin Pharmacol Ther. 2016 Dec 16. doi: 10.1002/cpt.583. [PubMed:27981572 ]

PMID: 9755289

Voriconazole

By

Voriconazole

Product: CAL-130 (Hydrochloride)

Identifier : DBSNPE005157
Drug : DB00582 (Voriconazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 1A>G (rs28399504 )

Allele Name : CYP2C19*4
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders
References :

  1. Moriyama B, Obeng AO, Barbarino J, Penzak SR, Henning SA, Scott SA, Agundez JA, Wingard JR, McLeod HL, Klein TE, Cross S, Caudle KE, Walsh TJ: Clinical Pharmacogenetics Implementation Consortium (CPIC(R)) Guideline for CYP2C19 and Voriconazole Therapy. Clin Pharmacol Ther. 2016 Dec 16. doi: 10.1002/cpt.583. [PubMed:27981572 ]

PMID: 8019769

Voriconazole

By

Voriconazole

Product: Salinomycin

Identifier : DBSNPE005158
Drug : DB00582 (Voriconazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 1297C>T (rs56337013 )

Allele Name : CYP2C19*5
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders
References :

  1. Moriyama B, Obeng AO, Barbarino J, Penzak SR, Henning SA, Scott SA, Agundez JA, Wingard JR, McLeod HL, Klein TE, Cross S, Caudle KE, Walsh TJ: Clinical Pharmacogenetics Implementation Consortium (CPIC(R)) Guideline for CYP2C19 and Voriconazole Therapy. Clin Pharmacol Ther. 2016 Dec 16. doi: 10.1002/cpt.583. [PubMed:27981572 ]

PMID: 8019770

Voriconazole

By

Voriconazole

Product: Pemetrexed (disodium)

Identifier : DBSNPE005159
Drug : DB00582 (Voriconazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 395G>A (rs72552267 )

Allele Name : CYP2C19*6
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders
References :

  1. Moriyama B, Obeng AO, Barbarino J, Penzak SR, Henning SA, Scott SA, Agundez JA, Wingard JR, McLeod HL, Klein TE, Cross S, Caudle KE, Walsh TJ: Clinical Pharmacogenetics Implementation Consortium (CPIC(R)) Guideline for CYP2C19 and Voriconazole Therapy. Clin Pharmacol Ther. 2016 Dec 16. doi: 10.1002/cpt.583. [PubMed:27981572 ]

PMID: 1330591

Voriconazole

By

Voriconazole

Product: Pemetrexed

Identifier : DBSNPE005160
Drug : DB00582 (Voriconazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 19294T>A (rs72558186 )

Allele Name : CYP2C19*7
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders
References :

  1. Moriyama B, Obeng AO, Barbarino J, Penzak SR, Henning SA, Scott SA, Agundez JA, Wingard JR, McLeod HL, Klein TE, Cross S, Caudle KE, Walsh TJ: Clinical Pharmacogenetics Implementation Consortium (CPIC(R)) Guideline for CYP2C19 and Voriconazole Therapy. Clin Pharmacol Ther. 2016 Dec 16. doi: 10.1002/cpt.583. [PubMed:27981572 ]

PMID: 27768754

Voriconazole

By

Voriconazole

Product: Bicalutamide

Identifier : DBSNPE005161
Drug : DB00582 (Voriconazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 557G>C (rs140278421 )
  • 991A>G

Allele Name : CYP2C19*22
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders
References :

  1. Moriyama B, Obeng AO, Barbarino J, Penzak SR, Henning SA, Scott SA, Agundez JA, Wingard JR, McLeod HL, Klein TE, Cross S, Caudle KE, Walsh TJ: Clinical Pharmacogenetics Implementation Consortium (CPIC(R)) Guideline for CYP2C19 and Voriconazole Therapy. Clin Pharmacol Ther. 2016 Dec 16. doi: 10.1002/cpt.583. [PubMed:27981572 ]

PMID: 25510459

Voriconazole

By

Voriconazole

Product: BMX-IN-1

Identifier : DBSNPE005162
Drug : DB00582 (Voriconazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 99C>T (rs17885098 )
  • 991A>G (rs3758581 )
  • 1004G>A (rs118203757 )
  • 1197A>G

Allele Name : CYP2C19*24
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders
References :

  1. Moriyama B, Obeng AO, Barbarino J, Penzak SR, Henning SA, Scott SA, Agundez JA, Wingard JR, McLeod HL, Klein TE, Cross S, Caudle KE, Walsh TJ: Clinical Pharmacogenetics Implementation Consortium (CPIC(R)) Guideline for CYP2C19 and Voriconazole Therapy. Clin Pharmacol Ther. 2016 Dec 16. doi: 10.1002/cpt.583. [PubMed:27981572 ]

PMID: 21357533

Voriconazole

By

Voriconazole

Product: Metiamide

Identifier : DBSNPE005163
Drug : DB00582 (Voriconazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 12662A>G (rs12769205 )

Allele Name : CYP2C19*35
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders
References :

  1. Moriyama B, Obeng AO, Barbarino J, Penzak SR, Henning SA, Scott SA, Agundez JA, Wingard JR, McLeod HL, Klein TE, Cross S, Caudle KE, Walsh TJ: Clinical Pharmacogenetics Implementation Consortium (CPIC(R)) Guideline for CYP2C19 and Voriconazole Therapy. Clin Pharmacol Ther. 2016 Dec 16. doi: 10.1002/cpt.583. [PubMed:27981572 ]

PMID: 11156581

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