PI3KInhibitorpi3kinhibitor

Tegafur

By

Tegafur

Product: BP-1-102

Identifier : DBSNPE000225
Drug : DB09256 (Tegafur)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Defining Change(s) :

  • G > A (rs3918290 )

Allele Name : DPYD*2A
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Non-functional DPYD
Description : Associated with 5-fluoracil toxicity
References :

  1. Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]

PMID: 2690429

Tegafur

By

Tegafur

Product: MK-8998

Identifier : DBSNPE000226
Drug : DB09256 (Tegafur)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Defining Change(s) :

  • A > C (rs55886062 )

Allele Name : DPYD*13
Genotype(s) : (C;C) / (A;C)
Type(s) : ADR Directly Studied
Groups : Non-functional DPYD
Description : Associated with 5-fluoracil toxicity
References :

  1. Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]

PMID: 3045827

Tegafur

By

Tegafur

Product: Importazole

Identifier : DBSNPE000227
Drug : DB09256 (Tegafur)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Defining Change(s) :

  • T > A (rs67376798 )

Allele Name : Not Available
Genotype(s) : (A;A) / (A;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with 5-fluoracil toxicity
References :

  1. Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]

PMID: 25307081

Tegafur

By

Tegafur

Product: PF-04957325

Identifier : DBSNPE000228
Drug : DB09256 (Tegafur)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Defining Change(s) :

  • G > A (rs1801158 )

Allele Name : DPYD*4
Genotype(s) : (G;G) / (A:G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with toxicity
References :

  1. Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]

PMID: 17351652

Tegafur

By

Tegafur

Product: DiI

Identifier : DBSNPE000229
Drug : DB09256 (Tegafur)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Defining Change(s) :

  • A > G (rs1801159 )

Allele Name : DPYD*5
Genotype(s) : (G;G) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with toxicity
References :

  1. Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]

PMID: 16432510

Tegafur

By

Tegafur

Product: Acumapimod

Identifier : DBSNPE000230
Drug : DB09256 (Tegafur)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Defining Change(s) :

  • G > A (rs1801160 )

Allele Name : DPYD*6
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with 5-fluoracil toxicity
References :

  1. Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]

PMID: 8632332

Tegafur

By

Tegafur

Product: AS1842856

Identifier : DBSNPE000231
Drug : DB09256 (Tegafur)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Defining Change(s) :

  • T > C (rs1801265 )

Allele Name : DPYD*9A
Genotype(s) : (C;C) / (C;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Associated with toxicity
References :

  1. Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]

PMID: 8287901

Tegafur

By

Tegafur

Product: BD-AcAc 3

Identifier : DBSNPE006023
Drug : DB09256 (Tegafur)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Defining Change(s) :

  • G > A (rs3918290 )

Allele Name : DPYD*2A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional DPYD
Description : Associated with 5-fluoracil toxicity
References :

  1. Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]

PMID: 26590637

Tegafur

By

Tegafur

Product: Medetomidine

Identifier : DBSNPE006024
Drug : DB09256 (Tegafur)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Defining Change(s) :

  • A > C (rs55886062 )

Allele Name : DPYD*13
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional DPYD
Description : Associated with 5-fluoracil toxicity
References :

  1. Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]

PMID: 17622149

Tegafur

By

Tegafur

Product: Rocuronium

Identifier : DBSNPE006025
Drug : DB09256 (Tegafur)
Interacting Gene/Enzyme : Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name : DPYD
UniProt ID : Q12882
Defining Change(s) :

  • T > A (rs67376798 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional DPYD
Description : Associated with 5-fluoracil toxicity
References :

  1. Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [PubMed:23988873 ]

PMID: 25898186

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