Tacrolimus
Identifier : DBSNPE000126
Drug : DB00864 (Tacrolimus)
Interacting Gene/Enzyme : Multidrug resistance protein 1
Gene Name : ABCB1
UniProt ID : P08183
Defining Change(s) :
- T Allele (G2677T) (rs2032582 )
Allele Name : Not Available
Genotype(s) : (T;T) / (G;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Increased risk of neurotoxicity
References :
- Yamauchi A, Ieiri I, Kataoka Y, Tanabe M, Nishizaki T, Oishi R, Higuchi S, Otsubo K, Sugimachi K: Neurotoxicity induced by tacrolimus after liver divansplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene. Transplantation. 2002 Aug 27;74(4):571-2. [PubMed:12352921 ]