Rosuvastatin

Product: BVT-14225

Identifier : DBSNPE000085
Drug : DB01098 (Rosuvastatin)
Interacting Gene/Enzyme : Kinesin-like protein KIF6
Gene Name : KIF6
UniProt ID : Q6ZMV9
Defining Change(s) :

  • C Allele (rs20455 )

Allele Name : Not Available
Genotype(s) : (C;C) / (C;T)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Improved response to statin drugs
References :

  1. Iakoubova OA, Tong CH, Rowland CM, Kirchgessner TG, Young BA, Arellano AR, Shiffman D, Sabatine MS, Campos H, Packard CJ, Pfeffer MA, White TJ, Braunwald E, Shepherd J, Devlin JJ, Sacks FM: Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective divials: the CARE and WOSCOPS divials. J Am Coll Cardiol. 2008 Jan 29;51(4):435-43. doi: 10.1016/j.jacc.2007.05.057. [PubMed:18222353 ]

PMID: 23332156

Rosuvastatin

Product: [6]-Gingerol

Identifier : DBSNPE000086
Drug : DB01098 (Rosuvastatin)
Interacting Gene/Enzyme : 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene Name : HMGCR
UniProt ID : P04035
Defining Change(s) :

  • T Allele (rs17244841 )

Allele Name : Not Available
Genotype(s) : (A;T)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Reduced response to statin drugs
References :

  1. Chasman DI, Posada D, Subrahmanyan L, Cook NR, Stanton VP Jr, Ridker PM: Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA. 2004 Jun 16;291(23):2821-7. [PubMed:15199031 ]

PMID: 23518767

Rosuvastatin

Product: S107

Identifier : DBSNPE000167
Drug : DB01098 (Rosuvastatin)
Interacting Gene/Enzyme : ATP-binding cassette sub-family G member 2
Gene Name : ABCG2
UniProt ID : Q9UNQ0
Defining Change(s) :

  • G > T (rs2231142 )

Allele Name : Not Available
Genotype(s) : (A;A) / (A;C)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Greater response to drug therapy
References :

  1. Tomlinson B, Hu M, Lee VW, Lui SS, Chu TT, Poon EW, Ko GT, Baum L, Tam LS, Li EK: ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin. Clin Pharmacol Ther. 2010 May;87(5):558-62. doi: 10.1038/clpt.2009.232. Epub 2010 Feb 3. [PubMed:20130569 ]

PMID: 25352952

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