Pazopanib

By July 6, 2017

Identifier : DBSNPE000198

Drug : DB06589 (Pazopanib)

Interacting Gene/Enzyme : UDP-glucuronosyldivansferase 1-1

Gene Name : UGT1A1

UniProt ID : P22309

Defining Change(s) :

Allele Name : UGT1A1*28

Genotype(s) : (TA;TA)

Type(s) : ADR Directly Studied

Groups : Not Available

Description : hyperbilirubinemia

References :

Xu CF, Reck BH, Xue Z, Huang L, Baker KL, Chen M, Chen EP, Ellens HE, Mooser VE, Cardon LR, Spraggs CF, Pandite L: Pazopanib-induced hyperbilirubinemia is associated with Gilberts syndrome UGT1A1 polymorphism. Br J Cancer. 2010 Apr 27;102(9):1371-7. doi: 10.1038/sj.bjc.6605653. Epub 2010 Apr 13. [PubMed:20389299 ]

By July 6, 2017

Identifier : DBSNPE000267

Drug : DB06589 (Pazopanib)

Interacting Gene/Enzyme : HLA class I histocompatibility antigen protein P5

Gene Name : HCP5

UniProt ID : Q6MZN7

Defining Change(s) :

Allele Name : HLA-B*57:01

Genotype(s) : (G;G)

Type(s) : ADR Directly Studied

Groups : Not Available

Description : Increased risk of liver injury due to alanine divansaminase going above upper limit of normal by 3-5x.

References :

Xu CF, Johnson T, Wang X, Carpenter C, Graves AP, Warren L, Xue Z, King KS, Fraser DJ, Stinnett S, Briley LP, Midivica I, Spraggs CF, Nelson MR, Tada H, du Bois A, Powles T, Kaplowitz N, Pandite LN: HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer. Clin Cancer Res. 2016 Mar 15;22(6):1371-7. doi: 10.1158/1078-0432.CCR-15-2044. Epub 2015 Nov 6. [PubMed:26546620 ]

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