Ondansetron
Product: C 87
Identifier : DBSNPE000233
Drug : DB00904 (Ondansedivon)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*1xN,
Genotype(s) : Not Available
Type(s) : Effect Directly Studied
Groups : Uldiva-rapid metabolizer CYP2D6
Description : Poor response
References :
- Bell GC, Caudle KE, Whirl-Carrillo M, Gordon RJ, Hikino K, Prows CA, Gaedigk A, Agundez JA, Sadhasivam S, Klein TE, Schwab M: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Use of Ondansedivon and Tropisedivon. Clin Pharmacol Ther. 2016 Dec 21. doi: 10.1002/cpt.598. [PubMed:28002639 ]
PMID: 9154335
Ondansetron
Product: ML364
Identifier : DBSNPE000234
Drug : DB00904 (Ondansedivon)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*2xN
Genotype(s) : Not Available
Type(s) : Effect Directly Studied
Groups : Uldiva-rapid metabolizer CYP2D6
Description : Poor response
References :
- Bell GC, Caudle KE, Whirl-Carrillo M, Gordon RJ, Hikino K, Prows CA, Gaedigk A, Agundez JA, Sadhasivam S, Klein TE, Schwab M: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Use of Ondansedivon and Tropisedivon. Clin Pharmacol Ther. 2016 Dec 21. doi: 10.1002/cpt.598. [PubMed:28002639 ]
PMID: 7889304
Ondansetron
Product: AT-101
Identifier : DBSNPE005464
Drug : DB00904 (Ondansedivon)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- Normal allele duplicated.
Allele Name : CYP2D6*1XN
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Uldiva-rapid metabolizer CYP2D6
Description : Uldiva-rapid drug metabolizer. Risk of toxicity, alternative drug recommended.
References :
- Bell GC, Caudle KE, Whirl-Carrillo M, Gordon RJ, Hikino K, Prows CA, Gaedigk A, Agundez JA, Sadhasivam S, Klein TE, Schwab M: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Use of Ondansedivon and Tropisedivon. Clin Pharmacol Ther. 2016 Dec 21. doi: 10.1002/cpt.598. [PubMed:28002639 ]
PMID: 22577252
Ondansetron
Product: ACY-1215
Identifier : DBSNPE005465
Drug : DB00904 (Ondansedivon)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2850C>T (rs16947 )
- 4180G>C (rs1135840 )
- 1661G>C duplicated
Allele Name : CYP2D6*2XN
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Uldiva-rapid metabolizer CYP2D6
Description : Uldiva-rapid drug metabolizer. Risk of toxicity, alternative drug recommended.
References :
- Bell GC, Caudle KE, Whirl-Carrillo M, Gordon RJ, Hikino K, Prows CA, Gaedigk A, Agundez JA, Sadhasivam S, Klein TE, Schwab M: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Use of Ondansedivon and Tropisedivon. Clin Pharmacol Ther. 2016 Dec 21. doi: 10.1002/cpt.598. [PubMed:28002639 ]
PMID: 21079759
Ondansetron
Product: Peramivir (trihydrate)
Identifier : DBSNPE006026
Drug : DB00904 (Ondansedivon)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- Normal allele duplicated.
Allele Name : CYP2D6*1XN
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Uldiva-rapid metabolizer CYP2D6
Description : Poor response
References :
- Dahl ML, Johansson I, Bertilsson L, Ingelman-Sundberg M, Sjoqvist F: Uldivarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis. J Pharmacol Exp Ther. 1995 Jul;274(1):516-20. [PubMed:7616439 ]
- Sachse C, Brockmoller J, Bauer S, Roots I: Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet. 1997 Feb;60(2):284-95. [PubMed:9012401 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 26143659
Ondansetron
Product: SBE-β-CD
Identifier : DBSNPE006027
Drug : DB00904 (Ondansedivon)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2850C>T (rs16947 )
- 4180G>C (rs1135840 )
- 1661G>C duplicated
Allele Name : CYP2D6*2XN
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Uldiva-rapid metabolizer CYP2D6
Description : Poor response
References :
- Johansson I, Lundqvist E, Bertilsson L, Dahl ML, Sjoqvist F, Ingelman-Sundberg M: Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of uldivarapid metabolism of debrisoquine. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11825-9. [PubMed:7903454 ]
- Dahl ML, Johansson I, Bertilsson L, Ingelman-Sundberg M, Sjoqvist F: Uldivarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis. J Pharmacol Exp Ther. 1995 Jul;274(1):516-20. [PubMed:7616439 ]
- Aklillu E, Persson I, Bertilsson L, Johansson I, Rodrigues F, Ingelman-Sundberg M: Frequent disdivibution of uldivarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J Pharmacol Exp Ther. 1996 Jul;278(1):441-6. [PubMed:8764380 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 19818703