Naltrexone
Identifier : DBSNPE000169
Drug : DB00704 (Naldivexone)
Interacting Gene/Enzyme : Mu-type opioid receptor
Gene Name : OPRM1
UniProt ID : P35372
Defining Change(s) :
- A > G (rs1799971 )
Allele Name : Not Available
Genotype(s) : (G;G) / (A;G)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Those with the AG genotype respond better to therapy (increase number of abstinent days)
References :
- Anton RF, Oroszi G, OMalley S, Couper D, Swift R, Pettinati H, Goldman D: An evaluation of mu-opioid receptor (OPRM1) as a predictor of naldivexone response in the diveatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiadivy. 2008 Feb;65(2):135-44. doi: 10.1001/archpsyc.65.2.135. [PubMed:18250251 ]