PI3KInhibitorpi3kinhibitor

Metoclopramide

By

Metoclopramide

Product: PAC-14028

Identifier : DBSNPE000187
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : Potassium voltage-gated channel subfamily H member 2
Gene Name : KCNH2
UniProt ID : Q12809
Defining Change(s) :

  • A > C (rs1805123 )

Allele Name : Not Available
Genotype(s) : (C;C) / (A;C)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Increased clinical efficacy
References :

  1. Parkman HP, Mishra A, Jacobs M, Pathikonda M, Sachdeva P, Gaughan J, Krynetskiy E: Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters. J Clin Gasdivoenterol. 2012 Jul;46(6):494-503. doi: 10.1097/MCG.0b013e3182522624. [PubMed:22688145 ]

PMID: 12902401

Metoclopramide

By

Metoclopramide

Product: Ecteinascidin 770

Identifier : DBSNPE000188
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : Alpha-1D adrenergic receptor
Gene Name : ADRA1D
UniProt ID : P25100
Defining Change(s) :

  • A > T (rs2236554 )

Allele Name : Not Available
Genotype(s) : (T;T) / (A;T)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Increased clinical efficacy
References :

  1. Parkman HP, Mishra A, Jacobs M, Pathikonda M, Sachdeva P, Gaughan J, Krynetskiy E: Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters. J Clin Gasdivoenterol. 2012 Jul;46(6):494-503. doi: 10.1097/MCG.0b013e3182522624. [PubMed:22688145 ]

PMID: 15308635

Metoclopramide

By

Metoclopramide

Product: SH5-07

Identifier : DBSNPE000189
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C > G (rs1080985 )

Allele Name : CYP2D6*2A
Genotype(s) : (G;G) / (C;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Increased side effects
References :

  1. Parkman HP, Mishra A, Jacobs M, Pathikonda M, Sachdeva P, Gaughan J, Krynetskiy E: Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters. J Clin Gasdivoenterol. 2012 Jul;46(6):494-503. doi: 10.1097/MCG.0b013e3182522624. [PubMed:22688145 ]

PMID: 9881874

Metoclopramide

By

Metoclopramide

Product: MELK-8a (hydrochloride)

Identifier : DBSNPE000190
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • G > A (rs16947 )

Allele Name : CYP2D6*2
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Increased side effects
References :

  1. Parkman HP, Mishra A, Jacobs M, Pathikonda M, Sachdeva P, Gaughan J, Krynetskiy E: Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters. J Clin Gasdivoenterol. 2012 Jul;46(6):494-503. doi: 10.1097/MCG.0b013e3182522624. [PubMed:22688145 ]

PMID: 1810591

Metoclopramide

By

Metoclopramide

Product: R121919

Identifier : DBSNPE000191
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • G > A (rs3892097 )

Allele Name : CYP2D6*4
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Increased side effects
References :

  1. Parkman HP, Mishra A, Jacobs M, Pathikonda M, Sachdeva P, Gaughan J, Krynetskiy E: Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters. J Clin Gasdivoenterol. 2012 Jul;46(6):494-503. doi: 10.1097/MCG.0b013e3182522624. [PubMed:22688145 ]

PMID: 26041925

Metoclopramide

By

Metoclopramide

Product: Chitosan

Identifier : DBSNPE000192
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : Potassium voltage-gated channel subfamily H member 2
Gene Name : KCNH2
UniProt ID : Q12809
Defining Change(s) :

  • C > T (rs3815459 )

Allele Name : Not Available
Genotype(s) : (T;T) / (C;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Increased side effects
References :

  1. Parkman HP, Mishra A, Jacobs M, Pathikonda M, Sachdeva P, Gaughan J, Krynetskiy E: Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters. J Clin Gasdivoenterol. 2012 Jul;46(6):494-503. doi: 10.1097/MCG.0b013e3182522624. [PubMed:22688145 ]

PMID: 25896608

Metoclopramide

By

Metoclopramide

Product: Dovitinib (lactate)

Identifier : DBSNPE000194
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : Multidrug resistance protein 1
Gene Name : ABCB1
UniProt ID : P08183
Defining Change(s) :

  • T Allele (rs1045642 )

Allele Name : Not Available
Genotype(s) : (T;T) / (C;T)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Poor response
References :

  1. Perwitasari DA, Wessels JA, van der Sdivaaten RJ, Baak-Pablo RF, Mustofa M, Hakimi M, Nortier JW, Gelderblom H, Guchelaar HJ: Association of ABCB1, 5-HT3B receptor and CYP2D6 genetic polymorphisms with ondansedivon and metoclopramide antiemetic response in Indonesian cancer patients diveated with highly emetogenic chemotherapy. Jpn J Clin Oncol. 2011 Oct;41(10):1168-76. doi: 10.1093/jjco/hyr117. Epub 2011 Aug 11. [PubMed:21840870 ]

PMID: 24345161

Metoclopramide

By

Metoclopramide

Product: MRT68921

Identifier : DBSNPE000195
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : Multidrug resistance protein 1
Gene Name : ABCB1
UniProt ID : P08183
Defining Change(s) :

  • G > T (rs2032582 )

Allele Name : Not Available
Genotype(s) : (T;T) / (G;T)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Poor response
References :

  1. Perwitasari DA, Wessels JA, van der Sdivaaten RJ, Baak-Pablo RF, Mustofa M, Hakimi M, Nortier JW, Gelderblom H, Guchelaar HJ: Association of ABCB1, 5-HT3B receptor and CYP2D6 genetic polymorphisms with ondansedivon and metoclopramide antiemetic response in Indonesian cancer patients diveated with highly emetogenic chemotherapy. Jpn J Clin Oncol. 2011 Oct;41(10):1168-76. doi: 10.1093/jjco/hyr117. Epub 2011 Aug 11. [PubMed:21840870 ]

PMID: 24732880

Metoclopramide

By

Metoclopramide

Product: Myricetin

Identifier : DBSNPE000196
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : Multidrug resistance protein 1
Gene Name : ABCB1
UniProt ID : P08183
Defining Change(s) :

  • C > T (rs1128503 )

Allele Name : Not Available
Genotype(s) : (T;T) / (C;T)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Poor response
References :

  1. Perwitasari DA, Wessels JA, van der Sdivaaten RJ, Baak-Pablo RF, Mustofa M, Hakimi M, Nortier JW, Gelderblom H, Guchelaar HJ: Association of ABCB1, 5-HT3B receptor and CYP2D6 genetic polymorphisms with ondansedivon and metoclopramide antiemetic response in Indonesian cancer patients diveated with highly emetogenic chemotherapy. Jpn J Clin Oncol. 2011 Oct;41(10):1168-76. doi: 10.1093/jjco/hyr117. Epub 2011 Aug 11. [PubMed:21840870 ]

PMID: 25147231

Metoclopramide

By

Metoclopramide

Product: HS-173

Identifier : DBSNPE000422
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 2 c.129C>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 23305385

Metoclopramide

By

Metoclopramide

Product: Auristatin PE

Identifier : DBSNPE000423
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 2 c.149G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 23184660

Metoclopramide

By

Metoclopramide

Product: Cinaciguat (hydrochloride)

Identifier : DBSNPE000424
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.162C>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 22723832

Metoclopramide

By

Metoclopramide

Product: Ciliobrevin A

Identifier : DBSNPE000425
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.173G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 21756268

Metoclopramide

By

Metoclopramide

Product: NSC632839

Identifier : DBSNPE000426
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.173G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 19535786

Metoclopramide

By

Metoclopramide

Product: Ibrutinib-biotin

Identifier : DBSNPE000427
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.194C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 17923257

Metoclopramide

By

Metoclopramide

Product: Mogrol

Identifier : DBSNPE000428
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.218T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 15790731

Metoclopramide

By

Metoclopramide

Product: Siamenoside I

Identifier : DBSNPE000429
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.226G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 15196329

Metoclopramide

By

Metoclopramide

Product: 11-oxo-mogroside V

Identifier : DBSNPE000430
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 4 c.229C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 18004284

Metoclopramide

By

Metoclopramide

Product: Beta-Sitosterol

Identifier : DBSNPE000431
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 4 c.247C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 18423777

Metoclopramide

By

Metoclopramide

Product: Naquotinib

Identifier : DBSNPE000432
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 4 c.287C>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 23349481

Metoclopramide

By

Metoclopramide

Product: Mirogabalin

Identifier : DBSNPE000433
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 4 c.316G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 22698981

Metoclopramide

By

Metoclopramide

Product: Pirmenol (hydrochloride)

Identifier : DBSNPE000434
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.350C>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 10951345

Metoclopramide

By

Metoclopramide

Product: GRA Ex-25

Identifier : DBSNPE000435
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.379A>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 8581274

Metoclopramide

By

Metoclopramide

Product: Norisoboldine

Identifier : DBSNPE000436
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.382T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 1855205

Metoclopramide

By

Metoclopramide

Product: Emetine (dihydrochloride hydrate)

Identifier : DBSNPE000437
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.434C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 28306507

Metoclopramide

By

Metoclopramide

Product: MKC3946

Identifier : DBSNPE000438
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.433C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 27713477

Metoclopramide

By

Metoclopramide

Product: Acebilustat

Identifier : DBSNPE000439
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.446T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 26759713

Metoclopramide

By

Metoclopramide

Product: KX2-391 (Mesylate)

Identifier : DBSNPE000440
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.478A>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 25616260

Metoclopramide

By

Metoclopramide

Product: TN1

Identifier : DBSNPE000441
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.478A>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 25491778

Metoclopramide

By

Metoclopramide

Product: OABK (hydrochloride)

Identifier : DBSNPE000442
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.536C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 25625755

Metoclopramide

By

Metoclopramide

Product: 8-Nitrotryptanthrin

Identifier : DBSNPE000443
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.535G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 24954507

Metoclopramide

By

Metoclopramide

Product: BLU-554

Identifier : DBSNPE000444
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.535G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 25687410

Metoclopramide

By

Metoclopramide

Product: NOD-IN-1

Identifier : DBSNPE000445
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.535G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 25885472

Metoclopramide

By

Metoclopramide

Product: Aloxistatin

Identifier : DBSNPE000446
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.535G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 25682200

Metoclopramide

By

Metoclopramide

Product: Disitertide

Identifier : DBSNPE000447
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 7 c.610T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 26479444

Metoclopramide

By

Metoclopramide

Product: Naquotinib (mesylate)

Identifier : DBSNPE000448
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 7 c.610T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 24849798

Metoclopramide

By

Metoclopramide

Product: RR6

Identifier : DBSNPE000449
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 7 c.611G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 25622528

Metoclopramide

By

Metoclopramide

Product: CC122

Identifier : DBSNPE000450
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.637G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 26664959

Metoclopramide

By

Metoclopramide

Product: KN-93 (phosphate)

Identifier : DBSNPE000451
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.647T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 26387946

Metoclopramide

By

Metoclopramide

Product: Cefamandole (sodium)

Identifier : DBSNPE000452
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.650T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 25923108

Metoclopramide

By

Metoclopramide

Product: Apoptozole

Identifier : DBSNPE000453
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.655C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 25674214

Metoclopramide

By

Metoclopramide

Product: Norverapamil (hydrochloride)

Identifier : DBSNPE000454
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.716T>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 26111662

Metoclopramide

By

Metoclopramide

Product: ML348

Identifier : DBSNPE000455
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.719A>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 26402163

Metoclopramide

By

Metoclopramide

Product: 7,4-Di-O-methylapigenin

Identifier : DBSNPE000456
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.719A>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 24758297

Metoclopramide

By

Metoclopramide

Product: trans-Trimethoxyresveratrol

Identifier : DBSNPE000457
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 Not reported

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 25409876

Metoclopramide

By

Metoclopramide

Product: Procyanidin B2

Identifier : DBSNPE000458
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.757G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 24443716

Metoclopramide

By

Metoclopramide

Product: Pranlukast (hemihydrate)

Identifier : DBSNPE000459
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.757G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 26005699

Metoclopramide

By

Metoclopramide

Product: PF-2545920 (hydrochloride)

Identifier : DBSNPE000460
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.757G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 24183378

Metoclopramide

By

Metoclopramide

Product: GSK2795039

Identifier : DBSNPE000461
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.757G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 25204804

Metoclopramide

By

Metoclopramide

Product: Velpatasvir

Identifier : DBSNPE000462
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.766_768del

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 24904530

Metoclopramide

By

Metoclopramide

Product: Sulfatinib

Identifier : DBSNPE000463
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.775C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 25360890

Metoclopramide

By

Metoclopramide

Product: Nelotanserin

Identifier : DBSNPE000464
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.815_817del

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 24658355

Metoclopramide

By

Metoclopramide

Product: YL0919

Identifier : DBSNPE000465
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.827C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 25012664

Metoclopramide

By

Metoclopramide

Product: U93631

Identifier : DBSNPE000466
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.875G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 23675751

Metoclopramide

By

Metoclopramide

Product: KPT-8602 (Z-isomer)

Identifier : DBSNPE000467
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.875G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 25534230

Metoclopramide

By

Metoclopramide

Product: alpha-Cyperone

Identifier : DBSNPE000468
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.875G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 23705924

Metoclopramide

By

Metoclopramide

Product: 4-Hydroxytamoxifen

Identifier : DBSNPE000469
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.882_884delinsAA

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 23868472

Metoclopramide

By

Metoclopramide

Product: Amiselimod (hydrochloride)

Identifier : DBSNPE000470
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.895_897del

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 23650283

Metoclopramide

By

Metoclopramide

Product: Buserelin (Acetate)

Identifier : DBSNPE000471
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 4 c.418-2A>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 23077105

Metoclopramide

By

Metoclopramide

Product: CHIR-99021 (trihydrochloride)

Identifier : DBSNPE000472
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 4 c.418-1G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 22989670

Metoclopramide

By

Metoclopramide

Product: CHIR-99021 (monohydrochloride)

Identifier : DBSNPE000473
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 5 c.548

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 23686416

Metoclopramide

By

Metoclopramide

Product: HTHQ

Identifier : DBSNPE000474
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 5 c.548

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 22825349

Metoclopramide

By

Metoclopramide

Product: HDAC-IN-4

Identifier : DBSNPE000475
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 5 c.547+2T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 22549111

Metoclopramide

By

Metoclopramide

Product: ML390

Identifier : DBSNPE000476
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 5 c.547+8G>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 22634477

Metoclopramide

By

Metoclopramide

Product: Amcasertib

Identifier : DBSNPE000477
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 6 c.631+1G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 23259680

Metoclopramide

By

Metoclopramide

Product: Sincalide

Identifier : DBSNPE000478
Drug : DB01233 (Metoclopramide)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 8 c.818-1G>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Karadsheh NS, Shaker Q, Radivoat B: Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue diveatment. Haematologica. 2001 Jun;86(6):659-60. [PubMed:11418378 ]
  2. Metoclopramide[package insert]. Baudette, Minnesota: ANI Pharmaceuticals Inc.; 2011. [Link]

PMID: 22962310

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