Mephenytoin
Product: Exendin-4 (Acetate)
Identifier : DBSNPE000019
Drug : DB00532 (Mephenytoin)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :
- A Allele, homozygote (rs4986893 )
Allele Name : CYP2C19*3
Genotype(s) : (A;A)
Type(s) : Effect Directly Studied
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement
References :
- De Morais SM, Wilkinson GR, Blaisdell J, Meyer UA, Nakamura K, Goldstein JA: Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol Pharmacol. 1994 Oct;46(4):594-8. [PubMed:7969038 ]
PMID: 18094329
Mephenytoin
Product: Columbin
Identifier : DBSNPE000184
Drug : DB00532 (Mephenytoin)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*8
Genotype(s) : (C;C) / (C;T)
Type(s) : Effect Directly Studied
Groups : Non-functional CYP2C19
Description : Poor metabolizer
References :
- Ibeanu GC, Blaisdell J, Ferguson RJ, Ghanayem BI, Brosen K, Benhamou S, Bouchardy C, Wilkinson GR, Dayer P, Goldstein JA: A novel divansversion in the indivon 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 condivibute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin. J Pharmacol Exp Ther. 1999 Aug;290(2):635-40. [PubMed:10411572 ]
PMID: 15615716
Mephenytoin
Product: Proguanil
Identifier : DBSNPE000185
Drug : DB00532 (Mephenytoin)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*7
Genotype(s) : (A;A) / (A;T)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Poor metabolizer
References :
- Ibeanu GC, Blaisdell J, Ferguson RJ, Ghanayem BI, Brosen K, Benhamou S, Bouchardy C, Wilkinson GR, Dayer P, Goldstein JA: A novel divansversion in the indivon 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 condivibute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin. J Pharmacol Exp Ther. 1999 Aug;290(2):635-40. [PubMed:10411572 ]
PMID: 15635152
Mephenytoin
Product: EMD-1214063
Identifier : DBSNPE005779
Drug : DB00532 (Mephenytoin)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*2A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement
References :
- de Morais SM, Wilkinson GR, Blaisdell J, Nakamura K, Meyer UA, Goldstein JA: The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J Biol Chem. 1994 Jun 3;269(22):15419-22. [PubMed:8195181 ]
- Fukushima-Uesaka H, Saito Y, Maekawa K, Ozawa S, Hasegawa R, Kajio H, Kuzuya N, Yasuda K, Kawamoto M, Kamatani N, Suzuki K, Yanagawa T, Tohkin M, Sawada J: Genetic variations and haplotypes of CYP2C19 in a Japanese population. Drug Metab Pharmacokinet. 2005 Aug;20(4):300-7. [PubMed:16141610 ]
- Lee SJ, Kim WY, Kim H, Shon JH, Lee SS, Shin JG: Identification of new CYP2C19 variants exhibiting decreased enzyme activity in the metabolism of S-mephenytoin and omeprazole. Drug Metab Dispos. 2009 Nov;37(11):2262-9. doi: 10.1124/dmd.109.028175. Epub 2009 Aug 6. [PubMed:19661214 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 21471379
Mephenytoin
Product: (R)-(-)-JQ1 Enantiomer
Identifier : DBSNPE005780
Drug : DB00532 (Mephenytoin)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*2B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement
References :
- Ibeanu GC, Goldstein JA, Meyer U, Benhamou S, Bouchardy C, Dayer P, Ghanayem BI, Blaisdell J: Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin. J Pharmacol Exp Ther. 1998 Sep;286(3):1490-5. [PubMed:9732415 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 15690449
Mephenytoin
Product: Clozapine
Identifier : DBSNPE005781
Drug : DB00532 (Mephenytoin)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement
References :
- De Morais SM, Wilkinson GR, Blaisdell J, Meyer UA, Nakamura K, Goldstein JA: Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol Pharmacol. 1994 Oct;46(4):594-8. [PubMed:7969038 ]
- Fukushima-Uesaka H, Saito Y, Maekawa K, Ozawa S, Hasegawa R, Kajio H, Kuzuya N, Yasuda K, Kawamoto M, Kamatani N, Suzuki K, Yanagawa T, Tohkin M, Sawada J: Genetic variations and haplotypes of CYP2C19 in a Japanese population. Drug Metab Pharmacokinet. 2005 Aug;20(4):300-7. [PubMed:16141610 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 24659806
Mephenytoin
Product: Alosetron (Hydrochloride)
Identifier : DBSNPE005782
Drug : DB00532 (Mephenytoin)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement
References :
- Ferguson RJ, De Morais SM, Benhamou S, Bouchardy C, Blaisdell J, Ibeanu G, Wilkinson GR, Sarich TC, Wright JM, Dayer P, Goldstein JA: A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin. J Pharmacol Exp Ther. 1998 Jan;284(1):356-61. [PubMed:9435198 ]
- Scott SA, Martis S, Peter I, Kasai Y, Kornreich R, Desnick RJ: Identification of CYP2C19*4B: pharmacogenetic implications for drug metabolism including clopidogrel responsiveness. Pharmacogenomics J. 2012 Aug;12(4):297-305. doi: 10.1038/tpj.2011.5. Epub 2011 Mar 1. [PubMed:21358751 ]
- Zackrisson AL, Lindblom B, Ahlner J: High frequency of occurrence of CYP2D6 gene duplication/multiduplication indicating uldivarapid metabolism among suicide cases. Clin Pharmacol Ther. 2010 Sep;88(3):354-9. doi: 10.1038/clpt.2009.216. Epub 2009 Nov 11. [PubMed:19907421 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 16834754
Mephenytoin
Product: Alosetron ((Z)-2-butenedioate)
Identifier : DBSNPE005783
Drug : DB00532 (Mephenytoin)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement
References :
- Xiao ZS, Goldstein JA, Xie HG, Blaisdell J, Wang W, Jiang CH, Yan FX, He N, Huang SL, Xu ZH, Zhou HH: Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele. J Pharmacol Exp Ther. 1997 Apr;281(1):604-9. [PubMed:9103550 ]
- Ibeanu GC, Blaisdell J, Ghanayem BI, Beyeler C, Benhamou S, Bouchardy C, Wilkinson GR, Dayer P, Daly AK, Goldstein JA: An additional defective allele, CYP2C19*5, condivibutes to the S-mephenytoin poor metabolizer phenotype in Caucasians. Pharmacogenetics. 1998 Apr;8(2):129-35. [PubMed:10022751 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 9618462
Mephenytoin
Product: Alosetron
Identifier : DBSNPE005784
Drug : DB00532 (Mephenytoin)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement
References :
- Ibeanu GC, Goldstein JA, Meyer U, Benhamou S, Bouchardy C, Dayer P, Ghanayem BI, Blaisdell J: Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin. J Pharmacol Exp Ther. 1998 Sep;286(3):1490-5. [PubMed:9732415 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 9407126
Mephenytoin
Product: Alosetron (Hydrochloride(1:X))
Identifier : DBSNPE005785
Drug : DB00532 (Mephenytoin)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement
References :
- Ibeanu GC, Blaisdell J, Ferguson RJ, Ghanayem BI, Brosen K, Benhamou S, Bouchardy C, Wilkinson GR, Dayer P, Goldstein JA: A novel divansversion in the indivon 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 condivibute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin. J Pharmacol Exp Ther. 1999 Aug;290(2):635-40. [PubMed:10411572 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 23146662
Mephenytoin
Product: Rimonabant
Identifier : DBSNPE005786
Drug : DB00532 (Mephenytoin)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :
- 557G>C (rs140278421 )
- 991A>G
Allele Name : CYP2C19*22
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement
References :
- Takahashi M, Saito T, Ito M, Tsukada C, Katono Y, Hosono H, Maekawa M, Shimada M, Mano N, Oda A, Hirasawa N, Hiratsuka M: Functional characterization of 21 CYP2C19 allelic variants for clopidogrel 2-oxidation. Pharmacogenomics J. 2015 Feb;15(1):26-32. doi: 10.1038/tpj.2014.30. Epub 2014 Jul 8. [PubMed:25001882 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 2334938
Mephenytoin
Product: Gemcitabine
Identifier : DBSNPE005787
Drug : DB00532 (Mephenytoin)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :
- 99C>T (rs17885098 )
- 991A>G (rs3758581 )
- 1004G>A (rs118203757 )
- 1197A>G
Allele Name : CYP2C19*24
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement
References :
- Zhou Q, Yu XM, Lin HB, Wang L, Yun QZ, Hu SN, Wang DM: Genetic polymorphism, linkage disequilibrium, haplotype sdivucture and novel allele analysis of CYP2C19 and CYP2D6 in Han Chinese. Pharmacogenomics J. 2009 Dec;9(6):380-94. doi: 10.1038/tpj.2009.31. Epub 2009 Jul 28. [PubMed:19636337 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 2720677
Mephenytoin
Product: Linagliptin
Identifier : DBSNPE005788
Drug : DB00532 (Mephenytoin)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Allele Name : CYP2C19*35
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement
References :
- Chaudhry AS, Prasad B, Shirasaka Y, Fohner A, Finkelstein D, Fan Y, Wang S, Wu G, Aklillu E, Sim SC, Thummel KE, Schuetz EG: The CYP2C19 Indivon 2 Branch Point SNP is the Ancesdival Polymorphism Condivibuting to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles. Drug Metab Dispos. 2015 Aug;43(8):1226-35. doi: 10.1124/dmd.115.064428. Epub 2015 May 28. [PubMed:26021325 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 3132318