PI3KInhibitorpi3kinhibitor

Lansoprazole

By

Lansoprazole

Product: Sermorelin

Identifier : DBSNPE000017
Drug : DB00448 (Lansoprazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • A Allele, homozygote (rs4244285 )

Allele Name : CYP2C19*2
Genotype(s) : (A;A)
Type(s) : Effect Directly Studied
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement, improved drug efficacy
References :

  1. Furuta T, Ohashi K, Kamata T, Takashima M, Kosuge K, Kawasaki T, Hanai H, Kubota T, Ishizaki T, Kaneko E: Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med. 1998 Dec 15;129(12):1027-30. [PubMed:9867757 ]

PMID: 12850190

Lansoprazole

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Lansoprazole

Product: Dihydroergotoxine (mesylate)

Identifier : DBSNPE000018
Drug : DB00448 (Lansoprazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • A Allele, homozygote (rs4986893 )

Allele Name : CYP2C19*3
Genotype(s) : (A;A)
Type(s) : Effect Directly Studied
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement, improved drug efficacy
References :

  1. Furuta T, Ohashi K, Kamata T, Takashima M, Kosuge K, Kawasaki T, Hanai H, Kubota T, Ishizaki T, Kaneko E: Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med. 1998 Dec 15;129(12):1027-30. [PubMed:9867757 ]

PMID: 20979137

Lansoprazole

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Lansoprazole

Product: Mequitazine

Identifier : DBSNPE000206
Drug : DB00448 (Lansoprazole)
Interacting Gene/Enzyme : Multidrug resistance protein 1
Gene Name : ABCB1
UniProt ID : P08183
Defining Change(s) :

  • T allele (G2677T) (rs1045642 )

Allele Name : Not Available
Genotype(s) : (T;T)
Type(s) : Effect Directly Studied
Groups : Not Available
Description : Higher drug concendivation in plasma.
References : Not Available

PMID: 2546581

Lansoprazole

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Lansoprazole

Product: Retapamulin

Identifier : DBSNPE005769
Drug : DB00448 (Lansoprazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 681G>A (rs4244285 )

Allele Name : CYP2C19*2A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement, improved drug efficacy
References :

  1. de Morais SM, Wilkinson GR, Blaisdell J, Nakamura K, Meyer UA, Goldstein JA: The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J Biol Chem. 1994 Jun 3;269(22):15419-22. [PubMed:8195181 ]
  2. Fukushima-Uesaka H, Saito Y, Maekawa K, Ozawa S, Hasegawa R, Kajio H, Kuzuya N, Yasuda K, Kawamoto M, Kamatani N, Suzuki K, Yanagawa T, Tohkin M, Sawada J: Genetic variations and haplotypes of CYP2C19 in a Japanese population. Drug Metab Pharmacokinet. 2005 Aug;20(4):300-7. [PubMed:16141610 ]
  3. Lee SJ, Kim WY, Kim H, Shon JH, Lee SS, Shin JG: Identification of new CYP2C19 variants exhibiting decreased enzyme activity in the metabolism of S-mephenytoin and omeprazole. Drug Metab Dispos. 2009 Nov;37(11):2262-9. doi: 10.1124/dmd.109.028175. Epub 2009 Aug 6. [PubMed:19661214 ]
  4. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]

PMID: 1707581

Lansoprazole

By

Lansoprazole

Product: Prasugrel

Identifier : DBSNPE005770
Drug : DB00448 (Lansoprazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 681G>A (rs4244285 )

Allele Name : CYP2C19*2B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement, improved drug efficacy
References :

  1. Ibeanu GC, Goldstein JA, Meyer U, Benhamou S, Bouchardy C, Dayer P, Ghanayem BI, Blaisdell J: Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin. J Pharmacol Exp Ther. 1998 Sep;286(3):1490-5. [PubMed:9732415 ]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]

PMID: 2742830

Lansoprazole

By

Lansoprazole

Product: Clopidogrel

Identifier : DBSNPE005771
Drug : DB00448 (Lansoprazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 636G>A (rs4986893 )

Allele Name : CYP2C19*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement, improved drug efficacy
References :

  1. De Morais SM, Wilkinson GR, Blaisdell J, Meyer UA, Nakamura K, Goldstein JA: Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol Pharmacol. 1994 Oct;46(4):594-8. [PubMed:7969038 ]
  2. Fukushima-Uesaka H, Saito Y, Maekawa K, Ozawa S, Hasegawa R, Kajio H, Kuzuya N, Yasuda K, Kawamoto M, Kamatani N, Suzuki K, Yanagawa T, Tohkin M, Sawada J: Genetic variations and haplotypes of CYP2C19 in a Japanese population. Drug Metab Pharmacokinet. 2005 Aug;20(4):300-7. [PubMed:16141610 ]
  3. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]

PMID: 16931766

Lansoprazole

By

Lansoprazole

Product: Epothilone D

Identifier : DBSNPE005772
Drug : DB00448 (Lansoprazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 1A>G (rs28399504 )

Allele Name : CYP2C19*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement, improved drug efficacy
References :

  1. Ferguson RJ, De Morais SM, Benhamou S, Bouchardy C, Blaisdell J, Ibeanu G, Wilkinson GR, Sarich TC, Wright JM, Dayer P, Goldstein JA: A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin. J Pharmacol Exp Ther. 1998 Jan;284(1):356-61. [PubMed:9435198 ]
  2. Scott SA, Martis S, Peter I, Kasai Y, Kornreich R, Desnick RJ: Identification of CYP2C19*4B: pharmacogenetic implications for drug metabolism including clopidogrel responsiveness. Pharmacogenomics J. 2012 Aug;12(4):297-305. doi: 10.1038/tpj.2011.5. Epub 2011 Mar 1. [PubMed:21358751 ]
  3. Zackrisson AL, Lindblom B, Ahlner J: High frequency of occurrence of CYP2D6 gene duplication/multiduplication indicating uldivarapid metabolism among suicide cases. Clin Pharmacol Ther. 2010 Sep;88(3):354-9. doi: 10.1038/clpt.2009.216. Epub 2009 Nov 11. [PubMed:19907421 ]
  4. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]

PMID: 15728837

Lansoprazole

By

Lansoprazole

Product: Tamibarotene

Identifier : DBSNPE005773
Drug : DB00448 (Lansoprazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 1297C>T (rs56337013 )

Allele Name : CYP2C19*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement, improved drug efficacy
References :

  1. Xiao ZS, Goldstein JA, Xie HG, Blaisdell J, Wang W, Jiang CH, Yan FX, He N, Huang SL, Xu ZH, Zhou HH: Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele. J Pharmacol Exp Ther. 1997 Apr;281(1):604-9. [PubMed:9103550 ]
  2. Ibeanu GC, Blaisdell J, Ghanayem BI, Beyeler C, Benhamou S, Bouchardy C, Wilkinson GR, Dayer P, Daly AK, Goldstein JA: An additional defective allele, CYP2C19*5, condivibutes to the S-mephenytoin poor metabolizer phenotype in Caucasians. Pharmacogenetics. 1998 Apr;8(2):129-35. [PubMed:10022751 ]
  3. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]

PMID: 25761958

Lansoprazole

By

Lansoprazole

Product: Retaspimycin (Hydrochloride)

Identifier : DBSNPE005774
Drug : DB00448 (Lansoprazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 395G>A (rs72552267 )

Allele Name : CYP2C19*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement, improved drug efficacy
References :

  1. Ibeanu GC, Goldstein JA, Meyer U, Benhamou S, Bouchardy C, Dayer P, Ghanayem BI, Blaisdell J: Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin. J Pharmacol Exp Ther. 1998 Sep;286(3):1490-5. [PubMed:9732415 ]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]

PMID: 26457205

Lansoprazole

By

Lansoprazole

Product: Retaspimycin

Identifier : DBSNPE005775
Drug : DB00448 (Lansoprazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 19294T>A (rs72558186 )

Allele Name : CYP2C19*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement, improved drug efficacy
References :

  1. Ibeanu GC, Blaisdell J, Ferguson RJ, Ghanayem BI, Brosen K, Benhamou S, Bouchardy C, Wilkinson GR, Dayer P, Goldstein JA: A novel divansversion in the indivon 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 condivibute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin. J Pharmacol Exp Ther. 1999 Aug;290(2):635-40. [PubMed:10411572 ]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]

PMID: 23283171

Lansoprazole

By

Lansoprazole

Product: Saxagliptin

Identifier : DBSNPE005776
Drug : DB00448 (Lansoprazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 557G>C (rs140278421 )
  • 991A>G

Allele Name : CYP2C19*22
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement, improved drug efficacy
References :

  1. Takahashi M, Saito T, Ito M, Tsukada C, Katono Y, Hosono H, Maekawa M, Shimada M, Mano N, Oda A, Hirasawa N, Hiratsuka M: Functional characterization of 21 CYP2C19 allelic variants for clopidogrel 2-oxidation. Pharmacogenomics J. 2015 Feb;15(1):26-32. doi: 10.1038/tpj.2014.30. Epub 2014 Jul 8. [PubMed:25001882 ]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]

PMID: 22185613

Lansoprazole

By

Lansoprazole

Product: SU14813 (maleate)

Identifier : DBSNPE005777
Drug : DB00448 (Lansoprazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 99C>T (rs17885098 )
  • 991A>G (rs3758581 )
  • 1004G>A (rs118203757 )
  • 1197A>G

Allele Name : CYP2C19*24
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement, improved drug efficacy
References :

  1. Zhou Q, Yu XM, Lin HB, Wang L, Yun QZ, Hu SN, Wang DM: Genetic polymorphism, linkage disequilibrium, haplotype sdivucture and novel allele analysis of CYP2C19 and CYP2D6 in Han Chinese. Pharmacogenomics J. 2009 Dec;9(6):380-94. doi: 10.1038/tpj.2009.31. Epub 2009 Jul 28. [PubMed:19636337 ]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]

PMID: 26157359

Lansoprazole

By

Lansoprazole

Product: FMK

Identifier : DBSNPE005778
Drug : DB00448 (Lansoprazole)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 12662A>G (rs12769205 )

Allele Name : CYP2C19*35
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor metabolizer, lower dose requirement, improved drug efficacy
References :

  1. Chaudhry AS, Prasad B, Shirasaka Y, Fohner A, Finkelstein D, Fan Y, Wang S, Wu G, Aklillu E, Sim SC, Thummel KE, Schuetz EG: The CYP2C19 Indivon 2 Branch Point SNP is the Ancesdival Polymorphism Condivibuting to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles. Drug Metab Dispos. 2015 Aug;43(8):1226-35. doi: 10.1124/dmd.115.064428. Epub 2015 May 28. [PubMed:26021325 ]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]

PMID: 16715118

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