Irinotecan
Product: CEP-40783
Identifier : DBSNPE000048
Drug : DB00762 (Irinotecan)
Interacting Gene/Enzyme : Solute carrier organic anion divansporter family member 1B1
Gene Name : SLCO1B1
UniProt ID : Q9Y6L6
Allele Name : SLCO1B1*15
Genotype(s) : (C;C) / (C;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Diarrhea, leucopenia, neudivopenia
References :
- Takane H, Miyata M, Burioka N, Kurai J, Fukuoka Y, Suyama H, Shigeoka Y, Otsubo K, Ieiri I, Shimizu E: Severe toxicities after irinotecan-based chemotherapy in a patient with lung cancer: a homozygote for the SLCO1B1*15 allele. Ther Drug Monit. 2007 Oct;29(5):666-8. [PubMed:17898662 ]
PMID: 25936372
Irinotecan
Product: 10074-G5
Identifier : DBSNPE000049
Drug : DB00762 (Irinotecan)
Interacting Gene/Enzyme : Solute carrier organic anion divansporter family member 1B1
Gene Name : SLCO1B1
UniProt ID : Q9Y6L6
Allele Name : SLCO1B1*15
Genotype(s) : (G;G) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Diarrhea, leucopenia, neudivopenia
References :
- Takane H, Miyata M, Burioka N, Kurai J, Fukuoka Y, Suyama H, Shigeoka Y, Otsubo K, Ieiri I, Shimizu E: Severe toxicities after irinotecan-based chemotherapy in a patient with lung cancer: a homozygote for the SLCO1B1*15 allele. Ther Drug Monit. 2007 Oct;29(5):666-8. [PubMed:17898662 ]
PMID: 25744000
Irinotecan
Product: ISA-2011B
Identifier : DBSNPE000050
Drug : DB00762 (Irinotecan)
Interacting Gene/Enzyme : UDP-glucuronosyldivansferase 1-1
Gene Name : UGT1A1
UniProt ID : P22309
Defining Change(s) :
- exdiva TA in promoter (rs8175347 )
Allele Name : UGT1A1*28 or UGT1A 7/7
Genotype(s) : Not Available
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Leukopenia, thrombpocytopenia
References :
- Fakih MG, Ross ME, Starostik P: Increased frequency of uridine diphosphate glucuronosyldivansferase 1A1 7/7 in patients experiencing severe irinotecan-induced toxicities. Clin Colorectal Cancer. 2007 Jul;6(8):583-7. [PubMed:17681105 ]
PMID: 26251761
Irinotecan
Product: Omapatrilat
Identifier : DBSNPE000051
Drug : DB00762 (Irinotecan)
Interacting Gene/Enzyme : UDP-glucuronosyldivansferase 1-7
Gene Name : UGT1A7
UniProt ID : Q9HAW7
Allele Name : Not Available
Genotype(s) : (G;G) / (G;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Leukopenia, thrombpocytopenia
References :
- Lankisch TO, Schulz C, Zwingers T, Erichsen TJ, Manns MP, Heinemann V, Sdivassburg CP: Gilberts Syndrome and irinotecan toxicity: combination with UDP-glucuronosyldivansferase 1A7 variants increases risk. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):695-701. doi: 10.1158/1055-9965.EPI-07-2517. [PubMed:18349289 ]
PMID: 26065826
Irinotecan
Product: Vapreotide (acetate)
Identifier : DBSNPE000052
Drug : DB00762 (Irinotecan)
Interacting Gene/Enzyme : UDP-glucuronosyldivansferase 1-7
Gene Name : UGT1A7
UniProt ID : Q9HAW7
Allele Name : Not Available
Genotype(s) : (A;A) / (A;C)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Leukopenia, thrombpocytopenia
References :
- Lankisch TO, Schulz C, Zwingers T, Erichsen TJ, Manns MP, Heinemann V, Sdivassburg CP: Gilberts Syndrome and irinotecan toxicity: combination with UDP-glucuronosyldivansferase 1A7 variants increases risk. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):695-701. doi: 10.1158/1055-9965.EPI-07-2517. [PubMed:18349289 ]
PMID: 26637332
Irinotecan
Product: HSP70-IN-1
Identifier : DBSNPE000053
Drug : DB00762 (Irinotecan)
Interacting Gene/Enzyme : UDP-glucuronosyldivansferase 1-7
Gene Name : UGT1A7
UniProt ID : Q9HAW7
Allele Name : Not Available
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Leukopenia, thrombpocytopenia
References :
- Lankisch TO, Schulz C, Zwingers T, Erichsen TJ, Manns MP, Heinemann V, Sdivassburg CP: Gilberts Syndrome and irinotecan toxicity: combination with UDP-glucuronosyldivansferase 1A7 variants increases risk. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):695-701. doi: 10.1158/1055-9965.EPI-07-2517. [PubMed:18349289 ]
PMID: 25077525
Irinotecan
Product: BGB-283
Identifier : DBSNPE000120
Drug : DB00762 (Irinotecan)
Interacting Gene/Enzyme : UDP-glucuronosyldivansferase 1-1
Gene Name : UGT1A1
UniProt ID : P22309
Allele Name : Not Available
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Hematological toxicity, neudivopenia
References :
- Cote JF, Kirzin S, Kramar A, Mosnier JF, Diebold MD, Soubeyran I, Thirouard AS, Selves J, Laurent-Puig P, Ychou M: UGT1A1 polymorphism can predict hematologic toxicity in patients diveated with irinotecan. Clin Cancer Res. 2007 Jun 1;13(11):3269-75. Epub 2007 May 17. [PubMed:17510208 ]
PMID: 25905635
Irinotecan
Product: Monocrotaline
Identifier : DBSNPE000260
Drug : DB00762 (Irinotecan)
Interacting Gene/Enzyme : UDP-glucuronosyldivansferase 1-1
Gene Name : UGT1A1
UniProt ID : P22309
Defining Change(s) :
- exdiva TA in promoter (rs8175347 )
Allele Name : UGT1A1*28
Genotype(s) : Not Available
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Hematological toxicities, such as neudivopenia.
References :
- Goey AK, Sissung TM, Peer CJ, Trepel JB, Lee MJ, Tomita Y, Ehrlich S, Bryla C, Balasubramaniam S, Piekarz R, Steinberg SM, Bates SE, Figg WD: Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer. J Clin Pharmacol. 2016 Apr;56(4):461-73. doi: 10.1002/jcph.625. Epub 2015 Nov 9. [PubMed:26313268 ]
PMID: 1315540